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10.1073/pnas.1615715114 http://scihub22266oqcxt.onion/10.1073/pnas.1615715114 C5676872!5676872 !29078267     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29078267 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Proc+Natl+Acad+Sci+U+S+A 2017 ; 114 (44 ): E9318-E9327 Nephropedia Template TP {{tp|p=29078267 |t=2017. Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood |pdf=|usr=}}{{29078267 }} gab.com Text Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078267 #FOAvip Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system (CNS) mainly in young adults, and a breakage of immune tolerance to CNS self-antigens has been suggested to initiate CNS autoimmunity. Age and microbial infection are well-known factors involved in the development of autoimmune diseases, including MS. Recent studies have suggested that alterations in the gut microbiota, referred to as dysbiosis, are associated with MS. However, it is still largely unknown how gut dysbiosis affects the onset and progression of CNS autoimmunity. In this study, we investigated the effects of age and gut dysbiosis on the development of CNS autoimmunity in humanized transgenic mice expressing the MS-associated MHC class II (MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived from an MS patient. We show here that the induction of gut dysbiosis triggers the development of spontaneous experimental autoimmune encephalomyelitis (EAE) during adolescence and early young adulthood, while an increase in immunological tolerance with aging suppresses disease onset after late young adulthood in mice. Furthermore, gut dysbiosis induces the expression of complement C3 and production of the anaphylatoxin C3a, and down-regulates the expression of the Foxp3 gene and anergy-related E3 ubiquitin ligase genes. Consequently, gut dysbiosis was able to trigger the development of encephalitogenic T cells and promote the induction of EAE during the age window of young adulthood. Twit Text FOAVip Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=29078267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29078267 #FOAvip English Wikipedia <ref>{{Cite pmid|29078267 }}</ref> Gut dysbiosis breaks immunological tolerance toward the central nervous system during young adulthood #MMPMID29078267 Yadav SK ; Boppana S ; Ito N ; Mindur JE ; Mathay MT ; Patel A ; Dhib-Jalbut S ; Ito K Proc Natl Acad Sci U S A 2017[Oct]; 114 (44 ): E9318-E9327 PMID29078267 show ga Multiple sclerosis (MS) is an autoimmune disease targeting the central nervous system (CNS) mainly in young adults, and a breakage of immune tolerance to CNS self-antigens has been suggested to initiate CNS autoimmunity. Age and microbial infection are well-known factors involved in the development of autoimmune diseases, including MS. Recent studies have suggested that alterations in the gut microbiota, referred to as dysbiosis, are associated with MS. However, it is still largely unknown how gut dysbiosis affects the onset and progression of CNS autoimmunity. In this study, we investigated the effects of age and gut dysbiosis on the development of CNS autoimmunity in humanized transgenic mice expressing the MS-associated MHC class II (MHC-II) gene, HLA-DR2a, and T-cell receptor (TCR) genes specific for MBP87-99/DR2a that were derived from an MS patient. We show here that the induction of gut dysbiosis triggers the development of spontaneous experimental autoimmune encephalomyelitis (EAE) during adolescence and early young adulthood, while an increase in immunological tolerance with aging suppresses disease onset after late young adulthood in mice. Furthermore, gut dysbiosis induces the expression of complement C3 and production of the anaphylatoxin C3a, and down-regulates the expression of the Foxp3 gene and anergy-related E3 ubiquitin ligase genes. Consequently, gut dysbiosis was able to trigger the development of encephalitogenic T cells and promote the induction of EAE during the age window of young adulthood. |Animals [MESH] |Autoimmunity/immunology [MESH] |Central Nervous System/*immunology [MESH] |Complement C3a/immunology [MESH] |Down-Regulation/immunology [MESH] |Dysbiosis/*immunology [MESH] |Encephalomyelitis, Autoimmune, Experimental/immunology [MESH] |Forkhead Transcription Factors/immunology [MESH] |Gastrointestinal Microbiome/*immunology [MESH] |Genes, MHC Class II/immunology [MESH] |HLA-DR2 Antigen/immunology [MESH] |Humans [MESH] |Immune Tolerance/*immunology [MESH] |Mice [MESH] |Mice, Transgenic [MESH] |Multiple Sclerosis/immunology [MESH] |Receptors, Antigen, T-Cell/immunology [MESH] |T-Lymphocytes/immunology [MESH]Gut dysbiosis breaks immunological tolerance toward the central nervou(epmc).pdf DeepDyve Pubget Overpricing