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Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancer+Chemother+Pharmacol 2017 ; 80 (5): 895-907 Nephropedia Template TP
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Electrolyte disorders with platinum-based chemotherapy: mechanisms, manifestations and management #MMPMID28730291
Oronsky B; Caroen S; Oronsky A; Dobalian VE; Oronsky N; Lybeck M; Reid TR; Carter CA
Cancer Chemother Pharmacol 2017[]; 80 (5): 895-907 PMID28730291show ga
Platinum chemotherapy, particularly cisplatin, is commonly associated with electrolyte imbalances, including hypomagnesemia, hypokalemia, hypophosphatemia, hypocalcemia and hyponatremia. The corpus of literature on these dyselectrolytemias is large; the objective of this review is to synthesize the literature and summarize the mechanisms responsible for these particular electrolyte disturbances in the context of platinum-based treatment as well as to present the clinical manifestations and current management strategies for oncologists and primary care physicians, since the latter are increasingly called on to provide care for cancer patients with medical comorbidities. Correct diagnosis and effective treatment are essential to improved patient outcomes.