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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Community+Hosp+Intern+Med+Perspect
2017 ; 7
(5
): 296-299
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Retrospective analysis of inferior vena cava collapsibility with point of care
ultrasound and urine sodium and FENa in patients with early stage acute kidney
injury
#MMPMID29147470
Babar F
; Singh G
; Noor M
; Sabath B
J Community Hosp Intern Med Perspect
2017[]; 7
(5
): 296-299
PMID29147470
show ga
Early stage acute kidney injury (AKI) is an independent risk factor for an
increase in mortality. Accurate assessment of volume status is a major challenge
during the early stages of acute renal injury. Determining volume status based on
the history and physical exam lacks accuracy. Urine sodium and free excretion of
sodium (FENa) provide objective evidence of intravascular volume status when
interpreted carefully and is helpful to delineate prerenal from intrinsic renal
failure. In recent years point of care ultrasound has been used to assess volume
status. Our team conducted a retrospective chart review to assess the association
of inferior vena cava collapsibility by point of care ultrasound (POCUS) and
urine electrolytes (urine sodium, fractional excretion of sodium) during early
stage AKI (Stage 1-2 of KDIGO guidelines). We reviewed 150 cases based on the
provisional diagnosis. 36 patients met the criteria for further review. Using
bivariate analysis, we found a strong association between >50% IVC collapsibility
with FENa < 0.4% with an odds ratio 5.3 (CI 1.1-24.5, p = 0.04), and urine sodium
<20 meq/dl with an odds ratio of 6.7 (Cl 1.5-30, p = 0.02). Subsequently,
multivariate analysis and Spearman correlation showed an inverse relation between
IVC collapsibility and fractional excretion of sodium FENa (? = -0.4, p = 0.001)
and (r = -0.44, p = 0.01). These findings suggest the role of POCUS and urinary
markers in determining the intravascular volume status in AKI. POCUS is also
valuable to assess volume status in cases of renal failure where urine studies
are difficult to interpret.