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10.1038/s41598-017-15316-6

http://scihub22266oqcxt.onion/10.1038/s41598-017-15316-6
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suck abstract from ncbi


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pmid29116212      Sci+Rep 2017 ; 7 (ä): ä
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  • Causes of Death in Patients with Severe Aortic Stenosis: An Observational study #MMPMID29116212
  • Minamino-Muta E; Kato T; Morimoto T; Taniguchi T; Shiomi H; Nakatsuma K; Shirai S; Ando K; Kanamori N; Murata K; Kitai T; Kawase Y; Miyake M; Izumi C; Mitsuoka H; Kato M; Hirano Y; Matsuda S; Nagao K; Inada T; Murakami T; Takeuchi Y; Yamane K; Toyofuku M; Ishii M; Inoko M; Ikeda T; Komasa A; Tada E; Ishii K; Hotta K; Higashitani N; Jinnai T; Kato Y; Inuzuka Y; Maeda C; Morikami Y; Saito N; Sakata R; Minatoya K; Kimura T
  • Sci Rep 2017[]; 7 (ä): ä PMID29116212show ga
  • Whether patients with severe aortic stenosis (AS) die because of AS-related causes is an important issue for the management of these patients. We used data from CURRENT AS registry, a Japanese multicenter registry, to assess the causes of death in severe AS patients and to identify the factors associated with non-cardiac mortality. We enrolled 3815 consecutive patients with a median follow-up of 1176 days; the 1449 overall deaths comprised 802 (55.3%) from cardiac and 647 (44.7%) from non-cardiac causes. Heart failure (HF) (25.7%) and sudden death (13.0%) caused the most cardiac deaths, whereas infection (13.0%) and malignancy (11.1%) were the main non-cardiac causes. According to treatment strategies, infection was the most common cause of non-cardiac death, followed by malignancy, in both the initial aortic valve replacement (AVR) cohort (N?=?1197), and the conservative management cohort (N?=?2618). Both non-cardiac factors (age, male, body mass index <22, diabetes, prior history of stroke, dialysis, anemia, and malignancy) and cardiac factors (atrial fibrillation, ejection fraction <68%, and the initial AVR strategy) were associated with non-cardiac death. These findings highlight the importance of close monitoring of non-cardiac comorbidities, as well as HF and sudden death, to improve the mortality rate of severe AS patients.
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