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10.1021/acschembio.7b00527 http://scihub22266oqcxt.onion/10.1021/acschembio.7b00527 C5676454!5676454!28787124     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ACS+Chem+Biol 2017 ; 12 (9): 2436-47 Nephropedia Template TP {{tp|p=28787124|t=2017. Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway |pdf=|usr=}}{{28787124}} gab.com Text Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway JO: ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28787124 #FOAvip Here we describe three new small-molecule activators of BMP signaling found by high throughput screening of a library of ~600,000 small molecules. Using a cell-based luciferase assay in the BMP4-responsive human cervical carcinoma clonal cell line, C33A-2D2, we identified three compounds with similar chemotypes that each ventralize zebrafish embryos and stimulate increased expression of the BMP target genes, bmp2b and szl. Because these compounds ventralize zebrafish embryos, we have termed them ?ventromorphins.? As expected for BMP pathway activators, they induce the differentiation of C2C12 myoblasts to osteoblasts. Affymetrix RNA analysis confirmed the differentiation results and showed that ventromorphins treatment elicits a response similar to BMP4 treatment. Unlike Isoliquiritigenin (SJ000286237), a flavone that maximally activates the pathway after 24 hours of treatment, all three ventromorphins induced SMAD1/5/8 phosphorylation within 30 minutes of treatment and achieved peak activity within 1 hour, indicating that their responses are consistent with directly activated BMP signaling. Twit Text FOAVip Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway ????ACS Chem Biol http://www.kidney.de/pget.php?&tw=1&pmid=28787124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28787124 #FOAvip English Wikipedia <ref>{{Cite pmid|28787124}}</ref> Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathway #MMPMID28787124 Genthe JR; Min J; Farmer DM; Shelat AA; Grenet JA; Lin W; Finkelstein D; Vrijens K; Chen T; Guy RK; Clements WK; Roussel MF ACS Chem Biol 2017[Sep]; 12 (9): 2436-47 PMID28787124show ga Here we describe three new small-molecule activators of BMP signaling found by high throughput screening of a library of ~600,000 small molecules. Using a cell-based luciferase assay in the BMP4-responsive human cervical carcinoma clonal cell line, C33A-2D2, we identified three compounds with similar chemotypes that each ventralize zebrafish embryos and stimulate increased expression of the BMP target genes, bmp2b and szl. Because these compounds ventralize zebrafish embryos, we have termed them ?ventromorphins.? As expected for BMP pathway activators, they induce the differentiation of C2C12 myoblasts to osteoblasts. Affymetrix RNA analysis confirmed the differentiation results and showed that ventromorphins treatment elicits a response similar to BMP4 treatment. Unlike Isoliquiritigenin (SJ000286237), a flavone that maximally activates the pathway after 24 hours of treatment, all three ventromorphins induced SMAD1/5/8 phosphorylation within 30 minutes of treatment and achieved peak activity within 1 hour, indicating that their responses are consistent with directly activated BMP signaling. äVentromorphins: A new class of small molecule activators of the canoni(epmc).pdf DeepDyve Pubget Overpricing