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10.3389/fimmu.2017.01460 http://scihub22266oqcxt.onion/10.3389/fimmu.2017.01460 C5675854!5675854!29163527     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29163527&cmd=llinks): Failed to open stream: HTTP request failed! 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Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells |pdf=|usr=}}{{29163527}} gab.com Text Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29163527 #FOAvip Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently being clinically tested for their potential to stop or control undesired immune responses in autoimmunity, hematopoietic stem cell transplantation, and solid organ transplantation. Current clinical approaches aim to boost Tregs in vivo either by using Treg-promoting small molecules/proteins and/or by adoptive transfer of expanded Tregs. However, the applicability of Treg-based immunotherapies continues to be hindered by technical limitations related to cell isolation and expansion of a pure, well-characterized, and targeted Treg product. Efforts to overcome these limitations and improve Treg-directed therapies are now under intense investigation in animal models and pre-clinical studies. Here, we review cell and protein engineering-based approaches that aim to target different aspects of Treg biology including modulation of IL-2 signaling or FOXP3 expression, and targeted antigen-specificity using transgenic T cell receptors or chimeric antigen receptors. With the world-wide interest in engineered T cell therapy, these exciting new approaches have the potential to be rapidly implemented and developed into therapies that can effectively fine-tune immune tolerance. Twit Text FOAVip Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29163527 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29163527 #FOAvip English Wikipedia <ref>{{Cite pmid|29163527}}</ref> Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells #MMPMID29163527 Dawson NAJ; Vent-Schmidt J; Levings MK Front Immunol 2017[]; 8 (ä): ä PMID29163527show ga Regulatory T cells (Tregs) are potent suppressors of immune responses and are currently being clinically tested for their potential to stop or control undesired immune responses in autoimmunity, hematopoietic stem cell transplantation, and solid organ transplantation. Current clinical approaches aim to boost Tregs in vivo either by using Treg-promoting small molecules/proteins and/or by adoptive transfer of expanded Tregs. However, the applicability of Treg-based immunotherapies continues to be hindered by technical limitations related to cell isolation and expansion of a pure, well-characterized, and targeted Treg product. Efforts to overcome these limitations and improve Treg-directed therapies are now under intense investigation in animal models and pre-clinical studies. Here, we review cell and protein engineering-based approaches that aim to target different aspects of Treg biology including modulation of IL-2 signaling or FOXP3 expression, and targeted antigen-specificity using transgenic T cell receptors or chimeric antigen receptors. With the world-wide interest in engineered T cell therapy, these exciting new approaches have the potential to be rapidly implemented and developed into therapies that can effectively fine-tune immune tolerance. äEngineered Tolerance: Tailoring Development, Function, and Antigen-Spe(epmc).pdf DeepDyve Pubget Overpricing