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Membrane Rafts in T Cell Activation: A Spotlight on CD28 Costimulation #MMPMID29163534
Zumerle S; Molon B; Viola A
Front Immunol 2017[]; 8 (ä): ä PMID29163534show ga
Spatiotemporal compartmentalization of signaling pathways and second messengers is pivotal for cell biology and membrane rafts are, therefore, required for several lymphocyte functions. On the other hand, T cells have the specific necessity of tuning signaling amplification depending on the context in which the antigen is presented. In this review, we discuss of membrane rafts in the context of T cell signaling, focusing on CD28-mediated costimulation.