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10.1038/ni.3619 http://scihub22266oqcxt.onion/10.1038/ni.3619 C5675020!5675020!27841869     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Immunol 2017 ; 18 (1): 15-25 Nephropedia Template TP {{tp|p=27841869|t=2017. Lymph node S1P gradients position natural killer cells and regulate their interferon-? response |pdf=|usr=}}{{27841869}} gab.com Text Lymph node S1P gradients position natural killer cells and regulate their interferon- response JO: Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27841869 #FOAvip The lymph node periphery is an important site for many immune functions, from pathogen containment to T helper differentiation, yet the cues that position cells in this region are largely undefined. Here, using a sphingosine 1-phosphate (S1P) reporter, we found that cells sensed higher concentrations of S1P in the medullary cords than in the T zone, and the S1P transporter SPNS2 on lymphatic endothelial cells generated this gradient. Natural killer (NK) cells are located at the periphery of the lymph node, predominantly in the medulla, and we found that expression of SPNS2, S1P receptor 5 on NK cells, and CXCR4 were all required for NK cell localization during homeostasis and rapid interferon-? production by NK cells after challenge. Our findings elucidate the spatial cues for NK cell organization, and reveal a novel role of S1P in positioning cells within the medulla. Twit Text FOAVip Lymph node S1P gradients position natural killer cells and regulate their interferon- response ????Nat Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27841869 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27841869 #FOAvip English Wikipedia <ref>{{Cite pmid|27841869}}</ref> Lymph node S1P gradients position natural killer cells and regulate their interferon-? response #MMPMID27841869 Fang V; Chaluvadi VS; Ramos-Perez WD; Mendoza A; Baeyens A; Rivera R; Chun J; Cammer M; Schwab SR Nat Immunol 2017[Jan]; 18 (1): 15-25 PMID27841869show ga The lymph node periphery is an important site for many immune functions, from pathogen containment to T helper differentiation, yet the cues that position cells in this region are largely undefined. Here, using a sphingosine 1-phosphate (S1P) reporter, we found that cells sensed higher concentrations of S1P in the medullary cords than in the T zone, and the S1P transporter SPNS2 on lymphatic endothelial cells generated this gradient. Natural killer (NK) cells are located at the periphery of the lymph node, predominantly in the medulla, and we found that expression of SPNS2, S1P receptor 5 on NK cells, and CXCR4 were all required for NK cell localization during homeostasis and rapid interferon-? production by NK cells after challenge. Our findings elucidate the spatial cues for NK cell organization, and reveal a novel role of S1P in positioning cells within the medulla. äLymph node S1P gradients position natural killer cells and regulate th(epmc).pdf DeepDyve Pubget Overpricing