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10.1083/jcb.201702033 http://scihub22266oqcxt.onion/10.1083/jcb.201702033 C5674886!5674886 !28931556     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28931556 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28931556 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2017 ; 216 (11 ): 3509-3520 Nephropedia Template TP {{tp|p=28931556 |t=2017. Cancer-associated fibroblasts lead tumor invasion through integrin-?3-dependent fibronectin assembly |pdf=|usr=}}{{28931556 }} gab.com Text Cancer-associated fibroblasts lead tumor invasion through integrin- 3-dependent fibronectin assembly JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28931556 #FOAvip Cancer-associated fibroblasts (CAFs) are the most abundant cells of the tumor stroma. Their capacity to contract the matrix and induce invasion of cancer cells has been well documented. However, it is not clear whether CAFs remodel the matrix by other means, such as degradation, matrix deposition, or stiffening. We now show that CAFs assemble fibronectin (FN) and trigger invasion mainly via integrin-?v?3. In the absence of FN, contractility of the matrix by CAFs is preserved, but their ability to induce invasion is abrogated. When degradation is impaired, CAFs retain the capacity to induce invasion in an FN-dependent manner. The level of expression of integrins ?v and ?3 and the amount of assembled FN are directly proportional to the invasion induced by fibroblast populations. Our results highlight FN assembly and integrin-?v?3 expression as new hallmarks of CAFs that promote tumor invasion. Twit Text FOAVip Cancer-associated fibroblasts lead tumor invasion through integrin- 3-dependent fibronectin assembly ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28931556 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28931556 #FOAvip English Wikipedia <ref>{{Cite pmid|28931556 }}</ref> Cancer-associated fibroblasts lead tumor invasion through integrin-?3-dependent fibronectin assembly #MMPMID28931556 Attieh Y ; Clark AG ; Grass C ; Richon S ; Pocard M ; Mariani P ; Elkhatib N ; Betz T ; Gurchenkov B ; Vignjevic DM J Cell Biol 2017[Nov]; 216 (11 ): 3509-3520 PMID28931556 show ga Cancer-associated fibroblasts (CAFs) are the most abundant cells of the tumor stroma. Their capacity to contract the matrix and induce invasion of cancer cells has been well documented. However, it is not clear whether CAFs remodel the matrix by other means, such as degradation, matrix deposition, or stiffening. We now show that CAFs assemble fibronectin (FN) and trigger invasion mainly via integrin-?v?3. In the absence of FN, contractility of the matrix by CAFs is preserved, but their ability to induce invasion is abrogated. When degradation is impaired, CAFs retain the capacity to induce invasion in an FN-dependent manner. The level of expression of integrins ?v and ?3 and the amount of assembled FN are directly proportional to the invasion induced by fibroblast populations. Our results highlight FN assembly and integrin-?v?3 expression as new hallmarks of CAFs that promote tumor invasion. |*Cell Communication [MESH] |*Cell Movement [MESH] |Animals [MESH] |Cancer-Associated Fibroblasts/*metabolism/pathology [MESH] |Cell Line, Tumor [MESH] |Coculture Techniques [MESH] |Colonic Neoplasms/*metabolism/pathology [MESH] |Extracellular Matrix/*metabolism [MESH] |Fibronectins/*metabolism [MESH] |Integrin alphaV/genetics/metabolism [MESH] |Integrin alphaVbeta3/genetics/metabolism [MESH] |Integrin beta3/*metabolism [MESH] |Mice [MESH] |Neoplasm Invasiveness [MESH] |Proteolysis [MESH] |RNA Interference [MESH] |Signal Transduction [MESH] |Transfection [MESH]Cancer-associated fibroblasts lead tumor invasion through integrin-?3-(epmc).pdf DeepDyve Pubget Overpricing