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10.1083/jcb.201701176

http://scihub22266oqcxt.onion/10.1083/jcb.201701176
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C5674885!5674885!28912124
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suck abstract from ncbi


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pmid28912124      J+Cell+Biol 2017 ; 216 (11): 3785-98
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  • Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading #MMPMID28912124
  • Böttcher RT; Veelders M; Rombaut P; Faix J; Theodosiou M; Stradal TE; Rottner K; Zent R; Herzog F; Fässler R
  • J Cell Biol 2017[Nov]; 216 (11): 3785-98 PMID28912124show ga
  • Cell spreading relies on the coordinated and dynamic regulation of integrin-mediated adhesions and actin structures. Böttcher et al. show that in the periphery of adhering cells kindlin-2 binds paxillin to activate Rac1 and the Arp2/3 complex to allow for Rac1-mediated membrane protrusions.
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