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10.1083/jcb.201701176 http://scihub22266oqcxt.onion/10.1083/jcb.201701176 C5674885!5674885 !28912124     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28912124 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Cell+Biol 2017 ; 216 (11 ): 3785-3798 Nephropedia Template TP {{tp|p=28912124 |t=2017. Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading |pdf=|usr=}}{{28912124 }} gab.com Text Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading JO: J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28912124 #FOAvip Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 plays a central role for cell adhesion and membrane protrusion by directly binding and recruiting paxillin to nascent adhesions. Here, we report that kindlin-2 has a dual role during initial cell spreading: it binds paxillin via the pleckstrin homology and F0 domains to activate Rac1, and it directly associates with the Arp2/3 complex to induce Rac1-mediated membrane protrusions. Consistently, abrogation of kindlin-2 binding to Arp2/3 impairs lamellipodia formation and cell spreading. Our findings identify kindlin-2 as a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2/3 complex. Twit Text FOAVip Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading ????J Cell Biol http://www.kidney.de/pget.php?&tw=1&pmid=28912124 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28912124 #FOAvip English Wikipedia <ref>{{Cite pmid|28912124 }}</ref> Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions during initial cell spreading #MMPMID28912124 Böttcher RT ; Veelders M ; Rombaut P ; Faix J ; Theodosiou M ; Stradal TE ; Rottner K ; Zent R ; Herzog F ; Fässler R J Cell Biol 2017[Nov]; 216 (11 ): 3785-3798 PMID28912124 show ga Cell spreading requires the coupling of actin-driven membrane protrusion and integrin-mediated adhesion to the extracellular matrix. The integrin-activating adaptor protein kindlin-2 plays a central role for cell adhesion and membrane protrusion by directly binding and recruiting paxillin to nascent adhesions. Here, we report that kindlin-2 has a dual role during initial cell spreading: it binds paxillin via the pleckstrin homology and F0 domains to activate Rac1, and it directly associates with the Arp2/3 complex to induce Rac1-mediated membrane protrusions. Consistently, abrogation of kindlin-2 binding to Arp2/3 impairs lamellipodia formation and cell spreading. Our findings identify kindlin-2 as a key protein that couples cell adhesion by activating integrins and the induction of membrane protrusions by activating Rac1 and supplying Rac1 with the Arp2/3 complex. |*Cell Adhesion [MESH] |*Cell Shape [MESH] |Actin-Related Protein 2-3 Complex/genetics/*metabolism [MESH] |Animals [MESH] |Carrier Proteins/genetics/metabolism [MESH] |Cell Line [MESH] |Cytoskeletal Proteins/deficiency/genetics/*metabolism [MESH] |Fibroblasts/*metabolism [MESH] |Genotype [MESH] |Mice, Knockout [MESH] |Muscle Proteins/deficiency/genetics/*metabolism [MESH] |Neuropeptides/genetics/metabolism [MESH] |Paxillin/genetics/*metabolism [MESH] |Phenotype [MESH] |Protein Binding [MESH] |Protein Interaction Domains and Motifs [MESH] |Pseudopodia/*metabolism [MESH] |Signal Transduction [MESH] |Talin/deficiency/genetics [MESH]Kindlin-2 recruits paxillin and Arp2/3 to promote membrane protrusions(epmc).pdf DeepDyve Pubget Overpricing