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10.21037/jgo.2017.07.02 http://scihub22266oqcxt.onion/10.21037/jgo.2017.07.02 C5674252!5674252 !29184699     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29184699 &cmd=llinks): Failed to open stream: HTTP request failed! 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Pancreatic non-functioning neuroendocrine tumor: a new entity genetically related to Lynch syndrome |pdf=|usr=}}{{29184699 }} gab.com Text Pancreatic non-functioning neuroendocrine tumor: a new entity genetically related to Lynch syndrome JO: J Gastrointest Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29184699 #FOAvip Some pancreatic neuroendocrine tumors (P-NETs) are associated with hereditary syndromes. An association between Lynch syndrome (LS) and P-NETs has been suggested, however it has not been confirmed to date. We describe the first case associating LS and P-NETs. Here we report a 65-year-old woman who in the past 20 years presented two colorectal carcinomas (CRC) endometrial carcinoma (EC), infiltrating ductal breast carcinoma, small intestine adenocarcinoma, two non-functioning P-NETs and sebomatricoma. With the exception of one P-NET, all these conditions were associated with LS, as confirmed by immunohistochemistry (IHC) and polymerase chain reaction (PCR). LS is caused by a mutation of a mismatch repair (MMR) gene which leads to a loss of expression of its protein. CRC is the most common tumor, followed by EC. Pancreatic tumors have also been associated with LS. Diagnosis of LS is based on clinical criteria (Amsterdam II and Bethesda) and genetic study (MMR gene mutation). The association between LS and our patient's tumors was confirmed by IHC (loss of expression of proteins MLH1 and its dimer PMS2) and the detection of microsatellite instability (MSI) using PCR. Twit Text FOAVip Pancreatic non-functioning neuroendocrine tumor: a new entity genetically related to Lynch syndrome ????J Gastrointest Oncol http://www.kidney.de/pget.php?&tw=1&pmid=29184699 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29184699 #FOAvip English Wikipedia <ref>{{Cite pmid|29184699 }}</ref> Pancreatic non-functioning neuroendocrine tumor: a new entity genetically related to Lynch syndrome #MMPMID29184699 Serracant Barrera A ; Serra Pla S ; Blázquez Maña CM ; Salas RC ; García Monforte N ; Bejarano González N ; Romaguera Monzonis A ; Andreu Navarro FJ ; Bella Cueto MR ; Borobia FG J Gastrointest Oncol 2017[Oct]; 8 (5 ): E73-E79 PMID29184699 show ga Some pancreatic neuroendocrine tumors (P-NETs) are associated with hereditary syndromes. An association between Lynch syndrome (LS) and P-NETs has been suggested, however it has not been confirmed to date. We describe the first case associating LS and P-NETs. Here we report a 65-year-old woman who in the past 20 years presented two colorectal carcinomas (CRC) endometrial carcinoma (EC), infiltrating ductal breast carcinoma, small intestine adenocarcinoma, two non-functioning P-NETs and sebomatricoma. With the exception of one P-NET, all these conditions were associated with LS, as confirmed by immunohistochemistry (IHC) and polymerase chain reaction (PCR). LS is caused by a mutation of a mismatch repair (MMR) gene which leads to a loss of expression of its protein. CRC is the most common tumor, followed by EC. Pancreatic tumors have also been associated with LS. Diagnosis of LS is based on clinical criteria (Amsterdam II and Bethesda) and genetic study (MMR gene mutation). The association between LS and our patient's tumors was confirmed by IHC (loss of expression of proteins MLH1 and its dimer PMS2) and the detection of microsatellite instability (MSI) using PCR. äPancreatic non-functioning neuroendocrine tumor: a new entity genetica(epmc).pdf DeepDyve Pubget Overpricing