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10.1038/s41598-017-15160-8 http://scihub22266oqcxt.onion/10.1038/s41598-017-15160-8 C5673966!5673966 !29109423     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29109423 &cmd=llinks): Failed to open stream: HTTP request failed! 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Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8 |pdf=|usr=}}{{29109423 }} gab.com Text Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8 JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29109423 #FOAvip Autoantibody-mediated inflammation directed at resident kidney cells mediates lupus nephritis (LN) pathogenesis. This study investigated the role of miRNA in human mesangial cells (HMCs) stimulated with auto anti-dsDNA immunoglobulin (Ig)G antibodies. HMCs were treated with antibodies purified from active LN patients or non-specific IgG controls in the presence of normal serum. Aberrant miRNA was screened using high throughput sequencing. Anti-dsDNA IgG up-regulated 103 miRNAs and down-regulated 30 miRNAs. The miRNAs regulated genes in the cell cycle, catabolic processes, regulation of transcription and apoptosis signalling. miR-10a was highly abundant in HMCs but was specifically downregulated upon anti-dsDNA IgG induction. Interestingly, the expression of miR-10a in kidney biopsies from class III and IV LN patients (n?=?26) was downregulated compared with cadaveric donor kidneys (n?=?6). Functional studies highlighted the downstream regulator of miR-10a in the chemokine signalling and cell proliferation or apoptosis pathways. Luciferase assay confirmed for the first time that IL8 was a direct target of miR-10a in HMCs. In conclusion, anti-dsDNA IgG Ab down-regulated miR-10a expression in HMCs resulting in the induction of various target genes involved in HMC proliferation and chemokine expression. Twit Text FOAVip Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8 ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29109423 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29109423 #FOAvip English Wikipedia <ref>{{Cite pmid|29109423 }}</ref> Transcriptomic profiling in human mesangial cells using patient-derived lupus autoantibodies identified miR-10a as a potential regulator of IL8 #MMPMID29109423 Tangtanatakul P ; Thammasate B ; Jacquet A ; Reantragoon R ; Pisitkun T ; Avihingsanon Y ; Leelahavanichkul A ; Hirankarn N Sci Rep 2017[Nov]; 7 (1 ): 14517 PMID29109423 show ga Autoantibody-mediated inflammation directed at resident kidney cells mediates lupus nephritis (LN) pathogenesis. This study investigated the role of miRNA in human mesangial cells (HMCs) stimulated with auto anti-dsDNA immunoglobulin (Ig)G antibodies. HMCs were treated with antibodies purified from active LN patients or non-specific IgG controls in the presence of normal serum. Aberrant miRNA was screened using high throughput sequencing. Anti-dsDNA IgG up-regulated 103 miRNAs and down-regulated 30 miRNAs. The miRNAs regulated genes in the cell cycle, catabolic processes, regulation of transcription and apoptosis signalling. miR-10a was highly abundant in HMCs but was specifically downregulated upon anti-dsDNA IgG induction. Interestingly, the expression of miR-10a in kidney biopsies from class III and IV LN patients (n?=?26) was downregulated compared with cadaveric donor kidneys (n?=?6). Functional studies highlighted the downstream regulator of miR-10a in the chemokine signalling and cell proliferation or apoptosis pathways. Luciferase assay confirmed for the first time that IL8 was a direct target of miR-10a in HMCs. In conclusion, anti-dsDNA IgG Ab down-regulated miR-10a expression in HMCs resulting in the induction of various target genes involved in HMC proliferation and chemokine expression. |Adult [MESH] |Autoantibodies/*metabolism [MESH] |Female [MESH] |Gene Expression Profiling [MESH] |Gene Expression Regulation [MESH] |Humans [MESH] |Immunoglobulin G/metabolism [MESH] |Interleukin-6/metabolism [MESH] |Interleukin-8/*metabolism [MESH] |Lupus Nephritis/*immunology [MESH] |Male [MESH] |Mesangial Cells/*immunology [MESH] |MicroRNAs/*metabolism [MESH]Transcriptomic profiling in human mesangial cells using patient-derive(epmc).pdf DeepDyve Pubget Overpricing