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10.1002/cam4.1171 http://scihub22266oqcxt.onion/10.1002/cam4.1171 C5673921!5673921 !28980418     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28980418 &cmd=llinks): Failed to open stream: HTTP request failed! 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Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update |pdf=|usr=}}{{28980418 }} gab.com Text Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update JO: Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=28980418 #FOAvip Survival rates for patients with medulloblastoma have improved in the last decades but for those who relapse outcome is dismal and new approaches are needed. Emerging drugs have been tested in the last two decades within the context of phase I/II trials. In parallel, advances in genetic profiling have permitted to identify key molecular alterations for which new strategies are being developed. We performed a systematic review focused on the design and outcome of early-phase trials evaluating new agents in patients with relapsed medulloblastoma. PubMed, clinicaltrials.gov, and references from selected studies were screened to identify phase I/II studies with reported results between 2000 and 2015 including patients with medulloblastoma aged <18 years. A total of 718 studies were reviewed and 78 satisfied eligibility criteria. Of those, 69% were phase I; 31% phase II. Half evaluated conventional chemotherapeutics and 35% targeted agents. Overall, 662 patients with medulloblastoma/primitive neuroectodermal tumors were included. The study designs and the response assessments were heterogeneous, limiting the comparisons among trials and the correct identification of active drugs. Median (range) objective response rate (ORR) for patients with medulloblastoma in phase I/II studies was 0% (0-100) and 6.5% (0-50), respectively. Temozolomide containing regimens had a median ORR of 16.5% (0-100). Smoothened inhibitors trials had a median ORR of 8% (3-8). Novel drugs have shown limited activity against relapsed medulloblastoma. Temozolomide might serve as backbone for new combinations. Novel and more homogenous trial designs might facilitate the development of new drugs. Twit Text FOAVip Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update ????Cancer Med http://www.kidney.de/pget.php?&tw=1&pmid=28980418 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28980418 #FOAvip English Wikipedia <ref>{{Cite pmid|28980418 }}</ref> Medulloblastoma in children and adolescents: a systematic review of contemporary phase I and II clinical trials and biology update #MMPMID28980418 Bautista F ; Fioravantti V ; de Rojas T ; Carceller F ; Madero L ; Lassaletta A ; Moreno L Cancer Med 2017[Nov]; 6 (11 ): 2606-2624 PMID28980418 show ga Survival rates for patients with medulloblastoma have improved in the last decades but for those who relapse outcome is dismal and new approaches are needed. Emerging drugs have been tested in the last two decades within the context of phase I/II trials. In parallel, advances in genetic profiling have permitted to identify key molecular alterations for which new strategies are being developed. We performed a systematic review focused on the design and outcome of early-phase trials evaluating new agents in patients with relapsed medulloblastoma. PubMed, clinicaltrials.gov, and references from selected studies were screened to identify phase I/II studies with reported results between 2000 and 2015 including patients with medulloblastoma aged <18 years. A total of 718 studies were reviewed and 78 satisfied eligibility criteria. Of those, 69% were phase I; 31% phase II. Half evaluated conventional chemotherapeutics and 35% targeted agents. Overall, 662 patients with medulloblastoma/primitive neuroectodermal tumors were included. The study designs and the response assessments were heterogeneous, limiting the comparisons among trials and the correct identification of active drugs. Median (range) objective response rate (ORR) for patients with medulloblastoma in phase I/II studies was 0% (0-100) and 6.5% (0-50), respectively. Temozolomide containing regimens had a median ORR of 16.5% (0-100). Smoothened inhibitors trials had a median ORR of 8% (3-8). Novel drugs have shown limited activity against relapsed medulloblastoma. Temozolomide might serve as backbone for new combinations. Novel and more homogenous trial designs might facilitate the development of new drugs. |*Molecular Targeted Therapy [MESH] |Adolescent [MESH] |Angiogenesis Inhibitors/therapeutic use [MESH] |Antineoplastic Combined Chemotherapy Protocols/*therapeutic use [MESH] |Cerebellar Neoplasms/*drug therapy [MESH] |Child [MESH] |Clinical Trials, Phase I as Topic [MESH] |Clinical Trials, Phase II as Topic [MESH] |Dacarbazine/administration & dosage/analogs & derivatives [MESH] |Humans [MESH] |Medulloblastoma/*drug therapy [MESH] |Smoothened Receptor/antagonists & inhibitors [MESH]Medulloblastoma in children and adolescents: a systematic review of co(epmc).pdf DeepDyve Pubget Overpricing