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The ratio of circulating follicular T helper cell to follicular T regulatory cell
is correlated with disease activity in systemic lupus erythematosus
#MMPMID28709914
Xu B
; Wang S
; Zhou M
; Huang Y
; Fu R
; Guo C
; Chen J
; Zhao J
; Gaskin F
; Fu SM
; Yang N
Clin Immunol
2017[Oct]; 183
(?): 46-53
PMID28709914
show ga
Follicular T regulatory (Tfr) cells inhibit follicular T helper (Tfh) cells
mediated B cell responses. Tfh cells are involved in the pathogenesis of systemic
lupus erythematosus (SLE). However, the role of Tfr cells in SLE remains unclear.
The frequency of circulating Tfr and Tfh cells were examined in SLE patients and
healthy controls. The frequency of circulating Tfr cell decreased and Tfh/Tfr
ratio increased in SLE patients. Serum anti-dsDNA antibody level positively
correlated with frequency of Tfh cells and Tfh/Tfr ratios but negatively
correlated with the frequency of Tfr cells. Moreover, the frequency of Tfr and
Tfh/Tfr ratio but not that of Tfh was correlated with diseases activity. In
addition, increase in Tfr cell numbers and decrease in the Tfh/Tfr ratios were
observed with successful treatments. Thus, Tfr cells should be considered as a
biomarker for SLE and their role in the pathogenesis of SLE warrants further
investigation.
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