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10.1111/ajt.13623 http://scihub22266oqcxt.onion/10.1111/ajt.13623 C5672809!5672809!26601915     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2016 ; 16 (5): 1383-93 Nephropedia Template TP {{tp|p=26601915|t=2016. Glutamate receptor interacting protein 1 regulates CD4+ CTLA-4 expression and transplant rejection |pdf=|usr=}}{{26601915}} gab.com Text Glutamate receptor interacting protein 1 regulates CD4+ CTLA-4 expression and transplant rejection JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26601915 #FOAvip PDZ domains are common 80?90 amino acid regions named after the first three proteins discovered to share these domains: post-synaptic density 95, disc large, and zonula occludens. PDZ domain-containing proteins typically interact with the C-terminus of membrane receptors. Glutamate receptor interacting protein 1 (GRIP1), a 7 PDZ domain protein scaffold regulates glutamate receptor surface expression and trafficking in neurons. We have found that human and mouse T cells also express GRIP1. T cell-specific GRIP1?/? mice greater than 11 weeks of age had prolonged cardiac allograft survival. Compared to WT T cells, in vitro stimulated GRIP1?/? T cells had decreased expression of activation markers, and increased apoptotic surface marker expression. Surface expression of the strong T cell inhibitory molecule CTLA-4 was increased on GRIP1?/? T cells from mice greater than 11 weeks of age. CTLA-4 increases with T cell stimulation and its surface expression on GRIP1?/? T cells remained high after stimulation was removed indicating a possible internalization defect in GRIP1 deficient T cells. CTLA-4 blocking antibody treatment following heart transplantation led to complete rejection in T cell GRIP1?/? mice indicating that increased CTLA-4 surface expression contributed to the extended graft survival. Our data indicates that GRIP1 regulates T cell activation by regulating CTLA-4 surface expression. Twit Text FOAVip Glutamate receptor interacting protein 1 regulates CD4+ CTLA-4 expression and transplant rejection ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=26601915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26601915 #FOAvip English Wikipedia <ref>{{Cite pmid|26601915}}</ref> Glutamate receptor interacting protein 1 regulates CD4+ CTLA-4 expression and transplant rejection #MMPMID26601915 Modjeski K; Levy S; Ture S; Field D; Shi G; Ko K; Zhu Q; Morrell C Am J Transplant 2016[May]; 16 (5): 1383-93 PMID26601915show ga PDZ domains are common 80?90 amino acid regions named after the first three proteins discovered to share these domains: post-synaptic density 95, disc large, and zonula occludens. PDZ domain-containing proteins typically interact with the C-terminus of membrane receptors. Glutamate receptor interacting protein 1 (GRIP1), a 7 PDZ domain protein scaffold regulates glutamate receptor surface expression and trafficking in neurons. We have found that human and mouse T cells also express GRIP1. T cell-specific GRIP1?/? mice greater than 11 weeks of age had prolonged cardiac allograft survival. Compared to WT T cells, in vitro stimulated GRIP1?/? T cells had decreased expression of activation markers, and increased apoptotic surface marker expression. Surface expression of the strong T cell inhibitory molecule CTLA-4 was increased on GRIP1?/? T cells from mice greater than 11 weeks of age. CTLA-4 increases with T cell stimulation and its surface expression on GRIP1?/? T cells remained high after stimulation was removed indicating a possible internalization defect in GRIP1 deficient T cells. CTLA-4 blocking antibody treatment following heart transplantation led to complete rejection in T cell GRIP1?/? mice indicating that increased CTLA-4 surface expression contributed to the extended graft survival. Our data indicates that GRIP1 regulates T cell activation by regulating CTLA-4 surface expression. äGlutamate receptor interacting protein 1 regulates CD4+ CTLA-4 express(epmc).pdf DeepDyve Pubget Overpricing