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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Bone+Marrow+Transplant
2017 ; 52
(11
): 1495-1503
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Cardiopulmonary assessment of patients with systemic sclerosis for hematopoietic
stem cell transplantation: recommendations from the European Society for Blood
and Marrow Transplantation Autoimmune Diseases Working Party and collaborating
partners
#MMPMID28530671
Farge D
; Burt RK
; Oliveira MC
; Mousseaux E
; Rovira M
; Marjanovic Z
; de Vries-Bouwstra J
; Del Papa N
; Saccardi R
; Shah SJ
; Lee DC
; Denton C
; Alexander T
; Kiely DG
; Snowden JA
Bone Marrow Transplant
2017[Nov]; 52
(11
): 1495-1503
PMID28530671
show ga
Systemic sclerosis (SSc) is a rare disabling autoimmune disease with a similar
mortality to many cancers. Two randomized controlled trials of autologous
hematopoietic stem cell transplantation (AHSCT) for SSc have shown significant
improvement in organ function, quality of life and long-term survival compared to
standard therapy. However, transplant-related mortality (TRM) ranged from 3-10%
in patients undergoing HSCT. In SSc, the main cause of non-transplant and TRM is
cardiac related. We therefore updated the previously published guidelines for
cardiac evaluation, which should be performed in dedicated centers with expertize
in HSCT for SSc. The current recommendations are based on pre-transplant
cardiopulmonary evaluations combining pulmonary function tests, echocardiography,
cardiac magnetic resonance imaging and invasive hemodynamic testing, initiated at
Northwestern University (Chicago) and subsequently discussed and endorsed within
the EBMT ADWP in 2016.