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10.1038/s41598-017-15106-0 http://scihub22266oqcxt.onion/10.1038/s41598-017-15106-0 C5670218!5670218 !29101355     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29101355 &cmd=llinks): Failed to open stream: HTTP request failed! 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Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin |pdf=|usr=}}{{29101355 }} gab.com Text Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29101355 #FOAvip The human body is exposed to a wide range of particles of industrial, environmental or internal origin such as asbestos, alum, silica or crystals of urate, calcium phosphate, calcium oxalate, cystine or cholesterol. Phagocytic clearance of such particles involves neutrophils and macrophages. Here we report that neutrophils encountering such particles of diverse sizes and shapes undergo necrotic cell death, a process associated with the formation of neutrophil extracellular trap (NET)-like extracellular DNA. In human neutrophils receptor-interacting protein kinase (RIPK)-1 inhibition with necrostatin-1s or mixed lineage kinase domain-like (MLKL) inhibition with necrosulfonamide abrogated cell death and associated-neutrophil extracellular DNA release induced by all of the aforementioned particles. Similar results were obtained with Mlkl-deficient mice neutrophils for all particles in vitro. Furthermore, Mlkl-deficient mice lacked tophus formation upon injection of MSU crystals into subcutaneous air pouches. These findings imply that nano- or microparticle-induced neutrophil extracellular DNA release is the consequence of neutrophil necroptosis, a regulated form of cell necrosis defined by RIPK1-RIPK3-MLKL signaling. Interestingly, this finding was consistent across different particle sizes and shapes. The RIPK1-RIPK3-MLKL signaling pathway may represent a potential therapeutic target in nano- or microparticle-related diseases (crystallopathies). Twit Text FOAVip Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29101355 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29101355 #FOAvip English Wikipedia <ref>{{Cite pmid|29101355 }}</ref> Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin #MMPMID29101355 Desai J ; Foresto-Neto O ; Honarpisheh M ; Steiger S ; Nakazawa D ; Popper B ; Buhl EM ; Boor P ; Mulay SR ; Anders HJ Sci Rep 2017[Nov]; 7 (1 ): 15003 PMID29101355 show ga The human body is exposed to a wide range of particles of industrial, environmental or internal origin such as asbestos, alum, silica or crystals of urate, calcium phosphate, calcium oxalate, cystine or cholesterol. Phagocytic clearance of such particles involves neutrophils and macrophages. Here we report that neutrophils encountering such particles of diverse sizes and shapes undergo necrotic cell death, a process associated with the formation of neutrophil extracellular trap (NET)-like extracellular DNA. In human neutrophils receptor-interacting protein kinase (RIPK)-1 inhibition with necrostatin-1s or mixed lineage kinase domain-like (MLKL) inhibition with necrosulfonamide abrogated cell death and associated-neutrophil extracellular DNA release induced by all of the aforementioned particles. Similar results were obtained with Mlkl-deficient mice neutrophils for all particles in vitro. Furthermore, Mlkl-deficient mice lacked tophus formation upon injection of MSU crystals into subcutaneous air pouches. These findings imply that nano- or microparticle-induced neutrophil extracellular DNA release is the consequence of neutrophil necroptosis, a regulated form of cell necrosis defined by RIPK1-RIPK3-MLKL signaling. Interestingly, this finding was consistent across different particle sizes and shapes. The RIPK1-RIPK3-MLKL signaling pathway may represent a potential therapeutic target in nano- or microparticle-related diseases (crystallopathies). |Animals [MESH] |Calcium Oxalate/pharmacology [MESH] |Calcium Phosphates/pharmacology [MESH] |Cell Death/*drug effects/physiology [MESH] |Cholesterol/pharmacology [MESH] |Chromatin/*metabolism [MESH] |Extracellular Traps/*drug effects/metabolism [MESH] |Humans [MESH] |Mice [MESH] |Necrosis/*metabolism/pathology [MESH] |Neutrophils/*drug effects/metabolism/pathology [MESH] |Silicon Dioxide/pharmacology [MESH]Particles of different sizes and shapes induce neutrophil necroptosis (epmc).pdf DeepDyve Pubget Overpricing