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10.18632/oncotarget.18743

http://scihub22266oqcxt.onion/10.18632/oncotarget.18743
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C5669966!5669966!29137340
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suck abstract from ncbi


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pmid29137340      Oncotarget 2017 ; 8 (47): 83261-9
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  • Prognostic role of tumour-associated macrophages and macrophage scavenger receptor 1 in prostate cancer: a systematic review and meta-analysis #MMPMID29137340
  • Cao J; Liu J; Xu R; Zhu X; Zhao X; Qian BZ
  • Oncotarget 2017[Oct]; 8 (47): 83261-9 PMID29137340show ga
  • Recent studies suggested that the tumour associated macrophages may be associated with prostate cancer outcome. A meta-analysis was performed to evaluate the prognostic value of tumor associated macrophages and macrophage scavenger receptor 1, marker for a subset of macrophages, by pooled hazard ratio and 95% confidence intervals from qualified studies following a systemic search. The results indicate that higher infiltration of tumor associated macrophages predicts poor overall survival (HR=1.57, 95%CI: 1.15-1.98), but not biochemical recurrence (HR=1.01, 95%CI: 0.98-1.04) or recurrence-free survival (HR=1.03, 95%CI: 0.05-2.01). In contrast, elevated level of macrophage scavenger receptor 1 was significantly associated with better recurrence-free survival (HR=3.26, 95%CI: 1.22-5.29). Thus, our analysis confirmed the prognostic value of these markers in prostate cancer outcome. We also discussed potential causes of the controversies in the literature and future research directions.
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