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2017 ; 8
(47
): 83261-83269
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Prognostic role of tumour-associated macrophages and macrophage scavenger
receptor 1 in prostate cancer: a systematic review and meta-analysis
#MMPMID29137340
Cao J
; Liu J
; Xu R
; Zhu X
; Zhao X
; Qian BZ
Oncotarget
2017[Oct]; 8
(47
): 83261-83269
PMID29137340
show ga
Recent studies suggested that the tumour associated macrophages may be associated
with prostate cancer outcome. A meta-analysis was performed to evaluate the
prognostic value of tumor associated macrophages and macrophage scavenger
receptor 1, marker for a subset of macrophages, by pooled hazard ratio and 95%
confidence intervals from qualified studies following a systemic search. The
results indicate that higher infiltration of tumor associated macrophages
predicts poor overall survival (HR=1.57, 95%CI: 1.15-1.98), but not biochemical
recurrence (HR=1.01, 95%CI: 0.98-1.04) or recurrence-free survival (HR=1.03,
95%CI: 0.05-2.01). In contrast, elevated level of macrophage scavenger receptor 1
was significantly associated with better recurrence-free survival (HR=3.26,
95%CI: 1.22-5.29). Thus, our analysis confirmed the prognostic value of these
markers in prostate cancer outcome. We also discussed potential causes of the
controversies in the literature and future research directions.