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2017 ; 8
(47
): 83246-83250
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
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English Wikipedia
Effect of long non-coding RNA highly up-regulated in liver cancer (HULC) on the
prognosis of cancer: a meta-analysis
#MMPMID29137338
Li Y
; Liu YH
; Chen X
; Zhu YJ
; Zhang HB
; Li Y
; Bai JP
; Liu LR
; Qu YC
; Qu X
Oncotarget
2017[Oct]; 8
(47
): 83246-83250
PMID29137338
show ga
Some studies investigated the association between highly up-regulated in liver
cancer (HULC) and the overall survival (OS) of cancer. However, the results were
conflicted and inconclusive. Therefore, we performed this meta-analysis to
determine the association between HULC and the OS of cancer. A comprehensive
online search was conducted on Online electronic databases (PubMed, EMBASE, and
Wanfang database) from the earliest date to Aug 30, 2016. The strength of the
association was calculated with the HRs and respective 95% CIs. The expression of
HULC was significantly associated with OS of cancers (HR = 2.12; 95% CI 1.61 -
2.79; P<0.00001). In the subgroup analysis by ethnicity, the expression of HULC
was significantly associated with OS in Chinese patients (HR = 2.04; 95% CI 1.55
- 2.70; P<0.00001). In the subgroup analysis by cancer type, HULC was associated
with OS in osteosarcoma patients (HR = 3.36; 95% CI 1.02 - 11.07; P = 0.05) and
in gastric cancer patients (HR = 2.17; 95% CI 1.08 - 4.38; P = 0.03). We
performed the sensitivity analysis to assess the stability of the meta-analysis.
A significant association was found in studies with adjustment (HR = 2.01; 95% CI
1.35 - 2.99; P= 0.0006). In conclusion, this meta-analysis suggested that high
expression of HULC was significantly associated with OS of cancer.