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10.18632/oncotarget.19635 http://scihub22266oqcxt.onion/10.18632/oncotarget.19635 C5669944!5669944 !29137318     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 253.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29137318 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2017 ; 8 (47 ): 82991-83008 Nephropedia Template TP {{tp|p=29137318 |t=2017. miR-27a-3p targeting RXR? promotes colorectal cancer progression by activating Wnt/?-catenin pathway |pdf=|usr=}}{{29137318 }} gab.com Text miR-27a-3p targeting RXR promotes colorectal cancer progression by activating Wnt/ -catenin pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29137318 #FOAvip This study aimed to elucidate how miR-27a-3p modulates the Wnt/?-catenin signaling pathway to promote colorectal cancer (CRC) progression. Our results showed that the expression of miR-27a-3p was up-regulated in CRC and closely associated with histological differentiation, clinical stage, distant metastasis and CRC patients' survival. miR-27a-3p mimic suppressed apoptosis and promoted proliferation, migration, invasion of CRC cells in vitro and in vivo. Whereas miR-27a-3p inhibitor promoted apoptosis and suppressed proliferation, migration, invasion of CRC cells in vitro and in vivo. Furthermore, RXR? was the target gene of miR-27a-3p in CRC. miR-27a-3p expression negatively correlated with RXR? expression in CRC tissues. The underlining mechanism study showed that miR-27a-3p/RXR?/Wnt/?-catenin signaling pathway is involved in CRC progression. In conclusion, our findings first demonstrate that miR-27a-3p is a prognostic and/or potential therapeutic biomarker for CRC patients and RXR? as miR-27a-3p targeting gene plays an important role in activation of the Wnt/?-catenin pathway during CRC progression. Twit Text FOAVip miR-27a-3p targeting RXR promotes colorectal cancer progression by activating Wnt/ -catenin pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29137318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29137318 #FOAvip English Wikipedia <ref>{{Cite pmid|29137318 }}</ref> miR-27a-3p targeting RXR? promotes colorectal cancer progression by activating Wnt/?-catenin pathway #MMPMID29137318 Liang J ; Tang J ; Shi H ; Li H ; Zhen T ; Duan J ; Kang L ; Zhang F ; Dong Y ; Han A Oncotarget 2017[Oct]; 8 (47 ): 82991-83008 PMID29137318 show ga This study aimed to elucidate how miR-27a-3p modulates the Wnt/?-catenin signaling pathway to promote colorectal cancer (CRC) progression. Our results showed that the expression of miR-27a-3p was up-regulated in CRC and closely associated with histological differentiation, clinical stage, distant metastasis and CRC patients' survival. miR-27a-3p mimic suppressed apoptosis and promoted proliferation, migration, invasion of CRC cells in vitro and in vivo. Whereas miR-27a-3p inhibitor promoted apoptosis and suppressed proliferation, migration, invasion of CRC cells in vitro and in vivo. Furthermore, RXR? was the target gene of miR-27a-3p in CRC. miR-27a-3p expression negatively correlated with RXR? expression in CRC tissues. The underlining mechanism study showed that miR-27a-3p/RXR?/Wnt/?-catenin signaling pathway is involved in CRC progression. In conclusion, our findings first demonstrate that miR-27a-3p is a prognostic and/or potential therapeutic biomarker for CRC patients and RXR? as miR-27a-3p targeting gene plays an important role in activation of the Wnt/?-catenin pathway during CRC progression. ämiR-27a-3p targeting RXR? promotes colorectal cancer progression by ac(epmc).pdf DeepDyve Pubget Overpricing