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10.18632/oncotarget.19066 http://scihub22266oqcxt.onion/10.18632/oncotarget.19066 C5669880!5669880 !29137254     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29137254 &cmd=llinks): Failed to open stream: HTTP request failed! 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Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting ?-catenin signaling pathway |pdf=|usr=}}{{29137254 }} gab.com Text Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting -catenin signaling pathway JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29137254 #FOAvip Quaking-5 (QKI-5) belongs to the STAR (signal transduction and activation of RNA) family of RNA binding proteins and functions as a tumor suppressor in several human malignancies. In this study, we attempt to elucidate the role of QKI-5 in the pro-metastasis processes of lung cancer (LC) cells and the underlying mechanisms. We confirmed that QKI-5 was decreased in human LC tissues and cell lines, especially in high-metastatic cells. Moreover, QKI expression was positively correlated with LC patients' survival. Functional studies verified that QKI-5 suppressed migration, invasion and TGF-?1-induced epithelial-mesenchymal transition (EMT) of LC cells. Mechanistically, we affirmed that QKI-5 reduced ?-catenin level in LC cells via suppressing its translation and promoting its degradation, whereas QKI-5 promoter hypermethylation suppressed QKI-5 expression. Our findings indicate that QKI-5 inhibits pro-metastasis processes of LC cells through interdicting ?-catenin signaling pathway, and that QKI-5 promoter hypermethylation is a crucial epigenetic regulation reducing QKI-5 expression in LC cells, and reveal that QKI-5 is a potential prognostic biomarker for LC patients. Twit Text FOAVip Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting -catenin signaling pathway ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=29137254 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29137254 #FOAvip English Wikipedia <ref>{{Cite pmid|29137254 }}</ref> Quaking-5 suppresses aggressiveness of lung cancer cells through inhibiting ?-catenin signaling pathway #MMPMID29137254 Zhou X ; Li X ; Sun C ; Shi C ; Hua D ; Yu L ; Wen Y ; Hua F ; Wang Q ; Zhou Q ; Yu S Oncotarget 2017[Oct]; 8 (47 ): 82174-82184 PMID29137254 show ga Quaking-5 (QKI-5) belongs to the STAR (signal transduction and activation of RNA) family of RNA binding proteins and functions as a tumor suppressor in several human malignancies. In this study, we attempt to elucidate the role of QKI-5 in the pro-metastasis processes of lung cancer (LC) cells and the underlying mechanisms. We confirmed that QKI-5 was decreased in human LC tissues and cell lines, especially in high-metastatic cells. Moreover, QKI expression was positively correlated with LC patients' survival. Functional studies verified that QKI-5 suppressed migration, invasion and TGF-?1-induced epithelial-mesenchymal transition (EMT) of LC cells. Mechanistically, we affirmed that QKI-5 reduced ?-catenin level in LC cells via suppressing its translation and promoting its degradation, whereas QKI-5 promoter hypermethylation suppressed QKI-5 expression. Our findings indicate that QKI-5 inhibits pro-metastasis processes of LC cells through interdicting ?-catenin signaling pathway, and that QKI-5 promoter hypermethylation is a crucial epigenetic regulation reducing QKI-5 expression in LC cells, and reveal that QKI-5 is a potential prognostic biomarker for LC patients. äQuaking-5 suppresses aggressiveness of lung cancer cells through inhib(epmc).pdf DeepDyve Pubget Overpricing