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2017 ; 12
(11
): e0187379
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Distributed smoothed tree kernel for protein-protein interaction extraction from
the biomedical literature
#MMPMID29099838
Murugesan G
; Abdulkadhar S
; Natarajan J
PLoS One
2017[]; 12
(11
): e0187379
PMID29099838
show ga
Automatic extraction of protein-protein interaction (PPI) pairs from biomedical
literature is a widely examined task in biological information extraction.
Currently, many kernel based approaches such as linear kernel, tree kernel, graph
kernel and combination of multiple kernels has achieved promising results in PPI
task. However, most of these kernel methods fail to capture the semantic relation
information between two entities. In this paper, we present a special type of
tree kernel for PPI extraction which exploits both syntactic (structural) and
semantic vectors information known as Distributed Smoothed Tree kernel (DSTK).
DSTK comprises of distributed trees with syntactic information along with
distributional semantic vectors representing semantic information of the
sentences or phrases. To generate robust machine learning model composition of
feature based kernel and DSTK were combined using ensemble support vector machine
(SVM). Five different corpora (AIMed, BioInfer, HPRD50, IEPA, and LLL) were used
for evaluating the performance of our system. Experimental results show that our
system achieves better f-score with five different corpora compared to other
state-of-the-art systems.