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10.1161/JAHA.117.005973 http://scihub22266oqcxt.onion/10.1161/JAHA.117.005973 C5669195!5669195!28645936     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28645936&cmd=llinks): Failed to open stream: HTTP request failed! 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Angiopoietin?Like Protein 4 Is a High?Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type?2 Diabetic Patients |pdf=|usr=}}{{28645936}} gab.com Text Angiopoietin Like Protein 4 Is a High Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type 2 Diabetic Patients JO: J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28645936 #FOAvip Background: ANGPTL4 (angiopoietin?like protein 4) is a LPL (lipoprotein lipase) inhibitor and is present in high?density lipoprotein (HDL). However, it is not defined whether ANGPTL4 in HDLs could affect HDL metabolism and function in type 2 diabetes mellitus (T2DM). Methods and Results: ANGPTL4 levels in the circulation and HDLs were quantified in nondiabetic participants (n=201, 68.7% females) and T2DM patients (n=185, 66.5% females). HDLs were isolated from nondiabetic controls and T2DM patients to assess cholesterol efflux or subjected to endothelial lipase (EL)?overexpressed HEK293 cells for EL hydrolysis in vitro. The association between ANGPTL4 in HDLs and HDL components and function was analyzed in nondiabetic participants or diabetic patients, respectively. Plasma or HDLs of ANGPTL4+/+ and ANGPTL4?/? mice was subjected for cholesterol efflux or EL hydrolysis, respectively. ANGPTL4 levels in the plasma and HDLs were 1.7? and 2.0?fold higher in T2DM patients than nondiabetic controls, respectively (P<0.0001). Multivariable analysis demonstrated that per 1 doubling increase of ANGPTL4 levels in HDLs, the changes amounted to +0.27% cholesterol efflux (P=0.03), +0.06 ?g/mL apolipoprotein A?I (P=0.09) and ?9.41 ?g/L serum amyloid A (P=0.02) in nondiabetic controls. In T2DM patients, the corresponding estimates were ?0.06% cholesterol efflux (P=0.10), ?0.06 ?g/mL apolipoprotein A?I (P=0.38), and +3.64 ?g/L serum amyloid A (P=0.72). HDLs isolated from ANGPTL4?/? mice showed accelerated hydrolysis by EL and reduced cholesterol efflux compared with ANGPTL4+/+ littermates. Conclusions: Physically, ANGPTL4 in HDLs protected HDLs from hydrolysis. Resulting from increased circulating ANGPTL4 levels in T2DM, ANGPTL4 levels in HDLs were elevated but with compromised inhibitory effect on EL, leading to increased HDL hydrolysis and dysfunction. Twit Text FOAVip Angiopoietin Like Protein 4 Is a High Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type 2 Diabetic Patients ????J Am Heart Assoc http://www.kidney.de/pget.php?&tw=1&pmid=28645936 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28645936 #FOAvip English Wikipedia <ref>{{Cite pmid|28645936}}</ref> Angiopoietin?Like Protein 4 Is a High?Density Lipoprotein (HDL) Component for HDL Metabolism and Function in Nondiabetic Participants and Type?2 Diabetic Patients #MMPMID28645936 Yang L; Yu C; Wang X; Yuan S; Zhang L; Lang J; Zhao D; Feng Y J Am Heart Assoc 2017[Jun]; 6 (6): ä PMID28645936show ga Background: ANGPTL4 (angiopoietin?like protein 4) is a LPL (lipoprotein lipase) inhibitor and is present in high?density lipoprotein (HDL). However, it is not defined whether ANGPTL4 in HDLs could affect HDL metabolism and function in type 2 diabetes mellitus (T2DM). Methods and Results: ANGPTL4 levels in the circulation and HDLs were quantified in nondiabetic participants (n=201, 68.7% females) and T2DM patients (n=185, 66.5% females). HDLs were isolated from nondiabetic controls and T2DM patients to assess cholesterol efflux or subjected to endothelial lipase (EL)?overexpressed HEK293 cells for EL hydrolysis in vitro. The association between ANGPTL4 in HDLs and HDL components and function was analyzed in nondiabetic participants or diabetic patients, respectively. Plasma or HDLs of ANGPTL4+/+ and ANGPTL4?/? mice was subjected for cholesterol efflux or EL hydrolysis, respectively. ANGPTL4 levels in the plasma and HDLs were 1.7? and 2.0?fold higher in T2DM patients than nondiabetic controls, respectively (P<0.0001). Multivariable analysis demonstrated that per 1 doubling increase of ANGPTL4 levels in HDLs, the changes amounted to +0.27% cholesterol efflux (P=0.03), +0.06 ?g/mL apolipoprotein A?I (P=0.09) and ?9.41 ?g/L serum amyloid A (P=0.02) in nondiabetic controls. In T2DM patients, the corresponding estimates were ?0.06% cholesterol efflux (P=0.10), ?0.06 ?g/mL apolipoprotein A?I (P=0.38), and +3.64 ?g/L serum amyloid A (P=0.72). HDLs isolated from ANGPTL4?/? mice showed accelerated hydrolysis by EL and reduced cholesterol efflux compared with ANGPTL4+/+ littermates. Conclusions: Physically, ANGPTL4 in HDLs protected HDLs from hydrolysis. Resulting from increased circulating ANGPTL4 levels in T2DM, ANGPTL4 levels in HDLs were elevated but with compromised inhibitory effect on EL, leading to increased HDL hydrolysis and dysfunction. äAngiopoietin?Like Protein 4 Is a High?Density Lipoprotein (HDL) Compon(epmc).pdf DeepDyve Pubget Overpricing