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10.1016/j.bbrep.2015.06.001 http://scihub22266oqcxt.onion/10.1016/j.bbrep.2015.06.001 C5668662!5668662!29124154     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biochem+Biophys+Rep 2015 ; 2 (ä): 132-6 Nephropedia Template TP {{tp|p=29124154|t=2015. Psoriasis pathogenesis ? Pso p27 constitutes a compact structure forming large aggregates |pdf=|usr=}}{{29124154}} gab.com Text Psoriasis pathogenesis Pso p27 constitutes a compact structure forming large aggregates JO: Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=29124154 #FOAvip Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed areas of the skin lesions argue for an immunological disease with a local production of a causal antigen. Pso p27 is a protein generated in mast cells in psoriatic plaques, but not in uninvolved skin. We recently demonstrated that the Pso p27 is generated by cleavage of SerpinB3 (SCCA1) in the presence of mast cell associated chymase.In this communication we demonstrate by X-ray crystallographic analysis that the cleavage products associate into a complex similar to SCCA1, but with the reactive centre loop inserted into a 5-stranded central ?-sheet.Native gel electrophoresis show that these Pso p27 complexes form large aggregates which may be of significance with respect to an immunogenic role of Pso p27. Twit Text FOAVip Psoriasis pathogenesis Pso p27 constitutes a compact structure forming large aggregates ????Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=29124154 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29124154 #FOAvip English Wikipedia <ref>{{Cite pmid|29124154}}</ref> Psoriasis pathogenesis ? Pso p27 constitutes a compact structure forming large aggregates #MMPMID29124154 Lysvand H; Helland R; Hagen L; Slupphaug G; Iversen OJ Biochem Biophys Rep 2015[Jul]; 2 (ä): 132-6 PMID29124154show ga Psoriasis is a chronic inflammatory skin disease. The absence of microbial organisms as potential causal agents has given rise to the hypothesis that the inflammation is due to an autoimmune reaction. The defined inflamed areas of the skin lesions argue for an immunological disease with a local production of a causal antigen. Pso p27 is a protein generated in mast cells in psoriatic plaques, but not in uninvolved skin. We recently demonstrated that the Pso p27 is generated by cleavage of SerpinB3 (SCCA1) in the presence of mast cell associated chymase.In this communication we demonstrate by X-ray crystallographic analysis that the cleavage products associate into a complex similar to SCCA1, but with the reactive centre loop inserted into a 5-stranded central ?-sheet.Native gel electrophoresis show that these Pso p27 complexes form large aggregates which may be of significance with respect to an immunogenic role of Pso p27. äPsoriasis pathogenesis ? Pso p27 constitutes a compact structure formi(epmc).pdf DeepDyve Pubget Overpricing