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10.1016/j.bbrep.2015.05.006 http://scihub22266oqcxt.onion/10.1016/j.bbrep.2015.05.006 C5668644!5668644 !29124146     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29124146 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Biochem+Biophys+Rep 2015 ; 2 (ä): 69-74 Nephropedia Template TP {{tp|p=29124146 |t=2015. Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG I?, a new auto-antigen in Sjögren?s syndrome patients, in salivary duct epithelial cells |pdf=|usr=}}{{29124146 }} gab.com Text Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG I , a new auto-antigen in Sjögren s syndrome patients, in salivary duct epithelial cells JO: Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=29124146 #FOAvip The regenerating gene, Reg, was originally isolated from a rat regenerating islet cDNA library, and its human homolog was named REG I?. Recently, we reported that REG I? mRNA as well as its product were overexpressed in ductal epithelial cells in the minor salivary glands of Sjögren?s syndrome (SS) patients. This study was undertaken to elucidate the role of cytokines and the subsequent intracellular mechanism for induction of REG I? in the salivary glands of SS patients. We prepared a reporter plasmid containing REG I? promoter (-1190/+26) upstream of a luciferase reporter gene. The promoter plasmid was introduced by lipofection into human NS-SV-DC and rat A5 salivary ductal cells. The cells were treated with interleukin (IL)-6, IL-8, and a combination of the two. Thereafter transcriptional activity of REG I? was measured by luciferase assay. We found that IL-6 stimulation, but not IL-8, significantly enhanced the REG I? promoter activity in salivary ductal cells. Deletion analysis revealed that the region of -141 to -117 of the REG I? gene was responsible for the promoter activation by IL-6, which contains a consensus sequence for signal transduction and activation of transcription (STAT). The introduction of siRNA for human STAT3 abolished IL-6-induced REG I? transcription. These results showed that IL-6 stimulation induced REG I? transcription through STAT3 activation and binding to the consensus sequence of REG I? promoter in salivary ductal cells. This IL-6/STAT dependent REG I? induction might play a role in the pathogenesis of SS. Twit Text FOAVip Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG I , a new auto-antigen in Sjögren s syndrome patients, in salivary duct epithelial cells ????Biochem Biophys Rep http://www.kidney.de/pget.php?&tw=1&pmid=29124146 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29124146 #FOAvip English Wikipedia <ref>{{Cite pmid|29124146 }}</ref> Interleukin-6/STAT pathway is responsible for the induction of gene expression of REG I?, a new auto-antigen in Sjögren?s syndrome patients, in salivary duct epithelial cells #MMPMID29124146 Fujimura T ; Fujimoto T ; Itaya-Hironaka A ; Miyaoka T ; Yoshimoto K ; Yamauchi A ; Sakuramoto-Tsuchida S ; Kondo S ; Takeda M ; Tsujinaka H ; Azuma M ; Tanaka Y ; Takasawa S Biochem Biophys Rep 2015[Jul]; 2 (ä): 69-74 PMID29124146 show ga The regenerating gene, Reg, was originally isolated from a rat regenerating islet cDNA library, and its human homolog was named REG I?. Recently, we reported that REG I? mRNA as well as its product were overexpressed in ductal epithelial cells in the minor salivary glands of Sjögren?s syndrome (SS) patients. This study was undertaken to elucidate the role of cytokines and the subsequent intracellular mechanism for induction of REG I? in the salivary glands of SS patients. We prepared a reporter plasmid containing REG I? promoter (-1190/+26) upstream of a luciferase reporter gene. The promoter plasmid was introduced by lipofection into human NS-SV-DC and rat A5 salivary ductal cells. The cells were treated with interleukin (IL)-6, IL-8, and a combination of the two. Thereafter transcriptional activity of REG I? was measured by luciferase assay. We found that IL-6 stimulation, but not IL-8, significantly enhanced the REG I? promoter activity in salivary ductal cells. Deletion analysis revealed that the region of -141 to -117 of the REG I? gene was responsible for the promoter activation by IL-6, which contains a consensus sequence for signal transduction and activation of transcription (STAT). The introduction of siRNA for human STAT3 abolished IL-6-induced REG I? transcription. These results showed that IL-6 stimulation induced REG I? transcription through STAT3 activation and binding to the consensus sequence of REG I? promoter in salivary ductal cells. This IL-6/STAT dependent REG I? induction might play a role in the pathogenesis of SS. äInterleukin-6/STAT pathway is responsible for the induction of gene ex(epmc).pdf DeepDyve Pubget Overpricing