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10.1111/jdi.12651 http://scihub22266oqcxt.onion/10.1111/jdi.12651 C5668485!5668485!28267275     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Diabetes+Investig 2017 ; 8 (6): 726-34 Nephropedia Template TP {{tp|p=28267275|t=2017. Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes |pdf=|usr=}}{{28267275}} gab.com Text Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes JO: J Diabetes Investig http://www.kidney.de/pget.php?&tw=1&pmid=28267275 #FOAvip Forkhead box class O family member proteins (FoxOs) of transcription factors are essential regulators of cellular homeostasis, including glucose and lipid metabolism, oxidative stress response and redox signaling, cell cycle progression, and apoptosis. Altered FoxO1 expression and activity have been associated with glucose intolerance, dyslipidemia and complications of diabetes. In the liver, they direct carbons to glucose or lipid utilization, thus providing a unifying mechanism for the two abnormalities of the diabetic liver: excessive glucose production, and increased lipid synthesis and secretion. In the pancreas, FoxO1 is necessary to maintain ??cell differentiation, and could be promising targets for ??cell regeneration. In endothelial cells, FoxOs strongly promote atherosclerosis through suppressing nitric oxide production and enhancing inflammatory responses. In the present review, we summarize the basic biology and pathophysiological significance of FoxOs in diabetes. Twit Text FOAVip Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes ????J Diabetes Investig http://www.kidney.de/pget.php?&tw=1&pmid=28267275 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28267275 #FOAvip English Wikipedia <ref>{{Cite pmid|28267275}}</ref> Forkhead box class O family member proteins: The biology and pathophysiological roles in diabetes #MMPMID28267275 Tsuchiya K; Ogawa Y J Diabetes Investig 2017[Nov]; 8 (6): 726-34 PMID28267275show ga Forkhead box class O family member proteins (FoxOs) of transcription factors are essential regulators of cellular homeostasis, including glucose and lipid metabolism, oxidative stress response and redox signaling, cell cycle progression, and apoptosis. Altered FoxO1 expression and activity have been associated with glucose intolerance, dyslipidemia and complications of diabetes. In the liver, they direct carbons to glucose or lipid utilization, thus providing a unifying mechanism for the two abnormalities of the diabetic liver: excessive glucose production, and increased lipid synthesis and secretion. In the pancreas, FoxO1 is necessary to maintain ??cell differentiation, and could be promising targets for ??cell regeneration. In endothelial cells, FoxOs strongly promote atherosclerosis through suppressing nitric oxide production and enhancing inflammatory responses. In the present review, we summarize the basic biology and pathophysiological significance of FoxOs in diabetes. äForkhead box class O family member proteins: The biology and pathophys(epmc).pdf DeepDyve Pubget Overpricing