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10.1038/s41598-017-14721-1 http://scihub22266oqcxt.onion/10.1038/s41598-017-14721-1 C5668412!5668412 !29097764     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29097764 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2017 ; 7 (1 ): 14973 Nephropedia Template TP {{tp|p=29097764 |t=2017. Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance |pdf=|usr=}}{{29097764 }} gab.com Text Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29097764 #FOAvip Parkinson disease (PD) is associated with multiple factors, including iron, which is demonstrated to deposit excessively in PD brains. We detected iron deposition by susceptibility weighted image (SWI) and measured the levels of iron metabolism-related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum of PD patients and control subjects. Clinical symptoms of PD were evaluated by series of rating scales. Relationships among above factors were analyzed. Results showed that corrected phase (CP) value of substantia nigra (SN) was significantly decreased in PD group compared to control group, hence, SN was the main region with excessive iron deposition. In PD group, ferritin was significantly elevated in CSF and reduced in serum compared to control group, and levels of ferritin in CSF and serum were both significantly and positively correlated with CP value of SN, thus, abnormal iron metabolism in central and peripheral systems was associated with iron deposition. CP value of SN in PD group was significantly and negatively correlated with interleukin-1? level in CSF, so interleukin-1? might be a neuroinflammatory factor produced by excessive iron in SN. Iron deposition in SN was significantly correlated with motor symptoms and part of non-motor symptoms of PD. Twit Text FOAVip Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29097764 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29097764 #FOAvip English Wikipedia <ref>{{Cite pmid|29097764 }}</ref> Iron deposition in substantia nigra: abnormal iron metabolism, neuroinflammatory mechanism and clinical relevance #MMPMID29097764 Liu Z ; Shen HC ; Lian TH ; Mao L ; Tang SX ; Sun L ; Huang XY ; Guo P ; Cao CJ ; Yu SY ; Zuo LJ ; Wang XM ; Chen SD ; Chan P ; Zhang W Sci Rep 2017[Nov]; 7 (1 ): 14973 PMID29097764 show ga Parkinson disease (PD) is associated with multiple factors, including iron, which is demonstrated to deposit excessively in PD brains. We detected iron deposition by susceptibility weighted image (SWI) and measured the levels of iron metabolism-related proteins and inflammatory factors in cerebrospinal fluid (CSF) and serum of PD patients and control subjects. Clinical symptoms of PD were evaluated by series of rating scales. Relationships among above factors were analyzed. Results showed that corrected phase (CP) value of substantia nigra (SN) was significantly decreased in PD group compared to control group, hence, SN was the main region with excessive iron deposition. In PD group, ferritin was significantly elevated in CSF and reduced in serum compared to control group, and levels of ferritin in CSF and serum were both significantly and positively correlated with CP value of SN, thus, abnormal iron metabolism in central and peripheral systems was associated with iron deposition. CP value of SN in PD group was significantly and negatively correlated with interleukin-1? level in CSF, so interleukin-1? might be a neuroinflammatory factor produced by excessive iron in SN. Iron deposition in SN was significantly correlated with motor symptoms and part of non-motor symptoms of PD. |Aged [MESH] |Female [MESH] |Humans [MESH] |Inflammation/*metabolism/pathology [MESH] |Iron/analysis/*metabolism [MESH] |Male [MESH] |Middle Aged [MESH] |Parkinson Disease/*metabolism/pathology [MESH]Iron deposition in substantia nigra: abnormal iron metabolism, neuroin(epmc).pdf DeepDyve Pubget Overpricing