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10.1038/s41598-017-13993-x http://scihub22266oqcxt.onion/10.1038/s41598-017-13993-x C5668375!5668375 !29097663     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29097663 &cmd=llinks): Failed to open stream: HTTP request failed! 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A model integrating tonic and antigen-triggered BCR signals to predict the survival of primary B cells |pdf=|usr=}}{{29097663 }} gab.com Text A model integrating tonic and antigen-triggered BCR signals to predict the survival of primary B cells JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29097663 #FOAvip The BCR constitutively transmits a "tonic" survival signal in the absence of exogenous antigen-binding. However, the strength of tonic BCR signal and its relationship with antigen-triggered survival signal are poorly understood. We found that primary B cells expressing high levels of BCR had elevated BCR tonic signal and increased survival compared with those expressing low levels of BCR. In addition, we found that crosslinking BCR with low doses of F(ab')(2) ?-IgM antibodies did not enhance, but rather decreased, B cell survival and that only when most of the BCR were occupied by F(ab')(2) ?-IgM antibodies was B cell survival enhanced. Based on these experimental results, we present a mathematical model integrating tonic and antigen-triggered BCR signals. Our model indicates that the signal generated from crosslinked BCR is 4.3 times as strong as the tonic signal generated from free BCR and that the threshold of B cell activation corresponds to the signal generated by crosslinking 61% of the surface BCR. This model also allows the prediction of the survival probability of a B cell based on its initial BCR level and the strength and duration of antigen stimulation, and fits with the mechanism of B cell tolerance. Twit Text FOAVip A model integrating tonic and antigen-triggered BCR signals to predict the survival of primary B cells ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29097663 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29097663 #FOAvip English Wikipedia <ref>{{Cite pmid|29097663 }}</ref> A model integrating tonic and antigen-triggered BCR signals to predict the survival of primary B cells #MMPMID29097663 Yasuda S ; Zhou Y ; Wang Y ; Yamamura M ; Wang JY Sci Rep 2017[Nov]; 7 (1 ): 14888 PMID29097663 show ga The BCR constitutively transmits a "tonic" survival signal in the absence of exogenous antigen-binding. However, the strength of tonic BCR signal and its relationship with antigen-triggered survival signal are poorly understood. We found that primary B cells expressing high levels of BCR had elevated BCR tonic signal and increased survival compared with those expressing low levels of BCR. In addition, we found that crosslinking BCR with low doses of F(ab')(2) ?-IgM antibodies did not enhance, but rather decreased, B cell survival and that only when most of the BCR were occupied by F(ab')(2) ?-IgM antibodies was B cell survival enhanced. Based on these experimental results, we present a mathematical model integrating tonic and antigen-triggered BCR signals. Our model indicates that the signal generated from crosslinked BCR is 4.3 times as strong as the tonic signal generated from free BCR and that the threshold of B cell activation corresponds to the signal generated by crosslinking 61% of the surface BCR. This model also allows the prediction of the survival probability of a B cell based on its initial BCR level and the strength and duration of antigen stimulation, and fits with the mechanism of B cell tolerance. |Animals [MESH] |B-Lymphocytes/*cytology/immunology [MESH] |Cell Survival [MESH] |Cells, Cultured [MESH] |Computer Simulation [MESH] |Immunoglobulin M/immunology [MESH] |Lymphocyte Activation [MESH] |Mice, Inbred C57BL [MESH] |Models, Biological [MESH]A model integrating tonic and antigen-triggered BCR signals to predict(epmc).pdf DeepDyve Pubget Overpricing