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10.1038/s41598-017-14780-4 http://scihub22266oqcxt.onion/10.1038/s41598-017-14780-4 C5668299!5668299 !29097726     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29097726 &cmd=llinks): Failed to open stream: HTTP request failed! 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Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1?-dependent decay |pdf=|usr=}}{{29097726 }} gab.com Text Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1 -dependent decay JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29097726 #FOAvip Long chain fatty acids (LCFAs) exert pro-inflammatory effects in vivo. However, little is known regarding the effect of LCFAs on invariant (i) NKT cell functions. Here, we report an inhibitory effect of saturated LCFAs on transcription factors in iNKT cells. Among the saturated LCFAs, palmitic acid (PA) specifically inhibited IL-4 and IFN-? production and reduced gata-3 and t-bet transcript levels in iNKT cells during TCR-mediated activation. In iNKT cells, PA was localized and induced dilation in the endoplasmic reticulum and increased the mRNA levels of downstream molecules of IRE1? RNase. Moreover, PA increased the degradation rates of gata-3 and t-bet mRNA, which was restored by IRE1? inhibition or transfection with mutant gata-3 or t-bet, indicating that gata-3 and t-bet are cleaved via regulated IRE1?-dependent decay (RIDD). A PA-rich diet and PA injection suppressed IL-4 and IFN-? production by iNKT cells in C57BL/6, but not J?18 knockout mice, which was restored by injection of STF083010, an IRE1?-specific inhibitor. Furthermore, a PA-rich diet and PA injection attenuated arthritis in an iNKT cell-dependent manner. Taken together, our experiments demonstrate that a saturated LCFA induced RIDD-mediated t-bet and gata-3 mRNA degradation in iNKT cells, thereby suppressing arthritis. Twit Text FOAVip Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1 -dependent decay ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=29097726 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29097726 #FOAvip English Wikipedia <ref>{{Cite pmid|29097726 }}</ref> Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degradation in iNKT cells via IRE1?-dependent decay #MMPMID29097726 Ko JS ; Koh JM ; So JS ; Jeon YK ; Kim HY ; Chung DH Sci Rep 2017[Nov]; 7 (1 ): 14940 PMID29097726 show ga Long chain fatty acids (LCFAs) exert pro-inflammatory effects in vivo. However, little is known regarding the effect of LCFAs on invariant (i) NKT cell functions. Here, we report an inhibitory effect of saturated LCFAs on transcription factors in iNKT cells. Among the saturated LCFAs, palmitic acid (PA) specifically inhibited IL-4 and IFN-? production and reduced gata-3 and t-bet transcript levels in iNKT cells during TCR-mediated activation. In iNKT cells, PA was localized and induced dilation in the endoplasmic reticulum and increased the mRNA levels of downstream molecules of IRE1? RNase. Moreover, PA increased the degradation rates of gata-3 and t-bet mRNA, which was restored by IRE1? inhibition or transfection with mutant gata-3 or t-bet, indicating that gata-3 and t-bet are cleaved via regulated IRE1?-dependent decay (RIDD). A PA-rich diet and PA injection suppressed IL-4 and IFN-? production by iNKT cells in C57BL/6, but not J?18 knockout mice, which was restored by injection of STF083010, an IRE1?-specific inhibitor. Furthermore, a PA-rich diet and PA injection attenuated arthritis in an iNKT cell-dependent manner. Taken together, our experiments demonstrate that a saturated LCFA induced RIDD-mediated t-bet and gata-3 mRNA degradation in iNKT cells, thereby suppressing arthritis. |Animals [MESH] |Arthritis/*drug therapy/genetics/immunology/pathology [MESH] |Cells, Cultured [MESH] |Endoribonucleases/*immunology [MESH] |GATA3 Transcription Factor/*genetics/immunology [MESH] |Mice, Inbred C57BL [MESH] |Natural Killer T-Cells/*drug effects/immunology/metabolism [MESH] |Palmitic Acid/pharmacology/*therapeutic use [MESH] |Protein Serine-Threonine Kinases/*immunology [MESH] |RNA Stability/*drug effects [MESH] |Signal Transduction/drug effects [MESH] |T-Box Domain Proteins/*genetics/immunology [MESH]Palmitate inhibits arthritis by inducing t-bet and gata-3 mRNA degrada(epmc).pdf DeepDyve Pubget Overpricing