Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29048387
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Int+J+Mol+Sci
2017 ; 18
(10
): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Vitamin D as a Novel Regulator of Tumor Metabolism: Insights on Potential
Mechanisms and Implications for Anti-Cancer Therapy
#MMPMID29048387
Abu El Maaty MA
; Wölfl S
Int J Mol Sci
2017[Oct]; 18
(10
): ä PMID29048387
show ga
1,25-dihydroxyvitamin D? [1,25(OH)?D?], the bioactive form of vitamin D, has been
shown to possess significant anti-tumor potential. While most studies so far have
focused on the ability of this molecule to influence the proliferation and
apoptosis of cancer cells, more recent data indicate that 1,25(OH)?D? also
impacts energy utilization in tumor cells. In this article, we summarize and
review the evidence that demonstrates the targeting of metabolic aberrations in
cancers by 1,25(OH)?D?, and highlight potential mechanisms through which these
effects may be executed. We shed light on the ability of this molecule to
regulate metabolism-related tumor suppressors and oncogenes, energy- and
nutrient-sensing pathways, as well as cell death and survival mechanisms such as
autophagy.
|Animals
[MESH]
|Antineoplastic Agents/*pharmacology/therapeutic use
[MESH]
|Apoptosis/drug effects
[MESH]
|Autophagy/drug effects
[MESH]
|Calcitriol/*metabolism/pharmacology/therapeutic use
[MESH]