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10.3390/ijms18102141 http://scihub22266oqcxt.onion/10.3390/ijms18102141 C5666823!5666823!29027962     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2017 ; 18 (10): ä Nephropedia Template TP {{tp|p=29027962|t=2017. Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms |pdf=|usr=}}{{29027962}} gab.com Text Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29027962 #FOAvip The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend?s hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection. On this basis, the possibility of treating MS with helminth infection has been explored in animal models and phase 1 and 2 human clinical trials. However, the possibility also exists that the individual immune modulatory molecules secreted by helminth parasites may offer a more defined therapeutic strategy. Twit Text FOAVip Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=29027962 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29027962 #FOAvip English Wikipedia <ref>{{Cite pmid|29027962}}</ref> Novel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms #MMPMID29027962 Dixit A; Tanaka A; Greer JM; Donnelly S Int J Mol Sci 2017[Oct]; 18 (10): ä PMID29027962show ga The evolutionary response to endemic infections with parasitic worms (helminth) was the development of a distinct regulatory immune profile arising from the need to encapsulate the helminths while simultaneously repairing tissue damage. According to the old friend?s hypothesis, the diminished exposure to these parasites in the developed world has resulted in a dysregulated immune response that contributes to the increased incidence of immune mediated diseases such as Multiple Sclerosis (MS). Indeed, the global distribution of MS shows an inverse correlation to the prevalence of helminth infection. On this basis, the possibility of treating MS with helminth infection has been explored in animal models and phase 1 and 2 human clinical trials. However, the possibility also exists that the individual immune modulatory molecules secreted by helminth parasites may offer a more defined therapeutic strategy. äNovel Therapeutics for Multiple Sclerosis Designed by Parasitic Worms (epmc).pdf DeepDyve Pubget Overpricing