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10.3390/ijms18102076 http://scihub22266oqcxt.onion/10.3390/ijms18102076 C5666758!5666758 !28973964     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28973964 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2017 ; 18 (10 ): ä Nephropedia Template TP {{tp|p=28973964 |t=2017. Topical Ocular Delivery of TGF-?1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases |pdf=|usr=}}{{28973964 }} gab.com Text Topical Ocular Delivery of TGF- 1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28973964 #FOAvip Dysregulation of the transforming growth factor-?1 (TGF-?1)/selected small mother against decapentaplegic (SMAD) pathway can be implicated in development of age-related macular degeneration (AMD), and the delivery of TGF-?1 could be beneficial for AMD. We developed a new ophthalmic formulation of TGF-?1 assessing the ocular pharmacokinetic profile of TGF-?1 in the rabbit eye. Small unilamellar vesicles (SUV) loaded with TGF-?1 were complemented with Annexin V and Ca(2+), and the vitreous bioavailability of TGF-?1 was assessed after topical ocular administration by a commercial ELISA kit. We detected high levels of TGF-?1 (C(max) 114.7 ± 12.40 pg/mL) in the vitreous after 60 min (T(max)) from the topical application of the liposomal suspension. Ocular tolerability was also assessed by a modified Draize's test. The new formulation was well tolerated. In conclusion, we demonstrated that the novel formulation was able to deliver remarkable levels of TGF-?1 into the back of the eye after topical administration. Indeed, this TGF-?1 delivery system may be useful in clinical practice to manage ophthalmic conditions such as age-related macular degeneration, skipping invasive intraocular injections. Twit Text FOAVip Topical Ocular Delivery of TGF- 1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=28973964 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28973964 #FOAvip English Wikipedia <ref>{{Cite pmid|28973964 }}</ref> Topical Ocular Delivery of TGF-?1 to the Back of the Eye: Implications in Age-Related Neurodegenerative Diseases #MMPMID28973964 Platania CBM ; Fisichella V ; Fidilio A ; Geraci F ; Lazzara F ; Leggio GM ; Salomone S ; Drago F ; Pignatello R ; Caraci F ; Bucolo C Int J Mol Sci 2017[Sep]; 18 (10 ): ä PMID28973964 show ga Dysregulation of the transforming growth factor-?1 (TGF-?1)/selected small mother against decapentaplegic (SMAD) pathway can be implicated in development of age-related macular degeneration (AMD), and the delivery of TGF-?1 could be beneficial for AMD. We developed a new ophthalmic formulation of TGF-?1 assessing the ocular pharmacokinetic profile of TGF-?1 in the rabbit eye. Small unilamellar vesicles (SUV) loaded with TGF-?1 were complemented with Annexin V and Ca(2+), and the vitreous bioavailability of TGF-?1 was assessed after topical ocular administration by a commercial ELISA kit. We detected high levels of TGF-?1 (C(max) 114.7 ± 12.40 pg/mL) in the vitreous after 60 min (T(max)) from the topical application of the liposomal suspension. Ocular tolerability was also assessed by a modified Draize's test. The new formulation was well tolerated. In conclusion, we demonstrated that the novel formulation was able to deliver remarkable levels of TGF-?1 into the back of the eye after topical administration. Indeed, this TGF-?1 delivery system may be useful in clinical practice to manage ophthalmic conditions such as age-related macular degeneration, skipping invasive intraocular injections. |Administration, Ophthalmic [MESH] |Animals [MESH] |Eye/*metabolism [MESH] |Humans [MESH] |Liposomes [MESH] |Macular Degeneration/drug therapy [MESH] |Models, Molecular [MESH] |Ophthalmic Solutions/administration & dosage/pharmacokinetics [MESH] |Rabbits [MESH] |Recombinant Proteins/administration & dosage/pharmacokinetics [MESH]Topical Ocular Delivery of TGF-?1 to the Back of the Eye: Implications(epmc).pdf DeepDyve Pubget Overpricing