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10.1101/gad.301697.117

http://scihub22266oqcxt.onion/10.1101/gad.301697.117
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C5666678!5666678!28982763
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suck abstract from ncbi


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pmid28982763      Genes+Dev 2017 ; 31 (17): 1809-20
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  • Integrator orchestrates RAS/ERK1/2 signaling transcriptional programs #MMPMID28982763
  • Yue J; Lai F; Beckedorff F; Zhang A; Pastori C; Shiekhattar R
  • Genes Dev 2017[Sep]; 31 (17): 1809-20 PMID28982763show ga
  • In this study, Yue et al. describe a new role for the RNAPII-associated complex Integrator in MAPK signaling. They show that Integrator mediates the transcriptional responsiveness following growth factor signaling, that depletion of Integrator can suppress MAPK signaling to the nucleus, and that Integrator could be targeted in MAPK-driven cancers that are resistant to conventional inhibitors of the MAPK pathway.
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