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10.15252/embr.201744200 http://scihub22266oqcxt.onion/10.15252/embr.201744200 C5666615!5666615!28855306     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Rep 2017 ; 18 (11): 1957-67 Nephropedia Template TP {{tp|p=28855306|t=2017. IL?23 drives differentiation of peripheral ??17 T cells from adult bone marrow?derived precursors |pdf=|usr=}}{{28855306}} gab.com Text IL 23 drives differentiation of peripheral 17 T cells from adult bone marrow derived precursors JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28855306 #FOAvip Pro?inflammatory interleukin (IL)?17?producing ?? (??17) T cells are thought to develop exclusively in the thymus during fetal/perinatal life, as adult bone marrow precursors fail to generate ??17 T cells under homeostatic conditions. Here, we employ a model of experimental autoimmune encephalomyelitis (EAE) in which hematopoiesis is reset by bone marrow transplantation and demonstrate unequivocally that V?4+ ??17 T cells can develop de novo in draining lymph nodes in response to innate stimuli. In vitro, ?? T cells from IL?17 fate?mapping reporter mice that had never activated the Il17 locus acquire IL?17 expression upon stimulation with IL?1? and IL?23. Furthermore, IL?23R (but not IL?1R1) deficiency severely compromises the induction of ??17 T cells in EAE, demonstrating the key role of IL?23 in the process. Finally, we show, in a composite model involving transfers of both adult bone marrow and neonatal thymocytes, that induced ??17 T cells make up a substantial fraction of the total IL?17?producing V?4+ T?cell pool upon inflammation, which attests the relevance of this novel pathway of peripheral ??17 T?cell differentiation. Twit Text FOAVip IL 23 drives differentiation of peripheral 17 T cells from adult bone marrow derived precursors ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28855306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28855306 #FOAvip English Wikipedia <ref>{{Cite pmid|28855306}}</ref> IL?23 drives differentiation of peripheral ??17 T cells from adult bone marrow?derived precursors #MMPMID28855306 Papotto PH; Gonçalves?Sousa N; Schmolka N; Iseppon A; Mensurado S; Stockinger B; Ribot JC; Silva?Santos B EMBO Rep 2017[Nov]; 18 (11): 1957-67 PMID28855306show ga Pro?inflammatory interleukin (IL)?17?producing ?? (??17) T cells are thought to develop exclusively in the thymus during fetal/perinatal life, as adult bone marrow precursors fail to generate ??17 T cells under homeostatic conditions. Here, we employ a model of experimental autoimmune encephalomyelitis (EAE) in which hematopoiesis is reset by bone marrow transplantation and demonstrate unequivocally that V?4+ ??17 T cells can develop de novo in draining lymph nodes in response to innate stimuli. In vitro, ?? T cells from IL?17 fate?mapping reporter mice that had never activated the Il17 locus acquire IL?17 expression upon stimulation with IL?1? and IL?23. Furthermore, IL?23R (but not IL?1R1) deficiency severely compromises the induction of ??17 T cells in EAE, demonstrating the key role of IL?23 in the process. Finally, we show, in a composite model involving transfers of both adult bone marrow and neonatal thymocytes, that induced ??17 T cells make up a substantial fraction of the total IL?17?producing V?4+ T?cell pool upon inflammation, which attests the relevance of this novel pathway of peripheral ??17 T?cell differentiation. äIL?23 drives differentiation of peripheral ??17 T cells from adult bon(epmc).pdf DeepDyve Pubget Overpricing