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10.15252/embr.201744200 http://scihub22266oqcxt.onion/10.15252/embr.201744200 C5666615!5666615 !28855306     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28855306 &cmd=llinks): Failed to open stream: HTTP request failed! 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IL-23 drives differentiation of peripheral ??17 T cells from adult bone marrow-derived precursors |pdf=|usr=}}{{28855306 }} gab.com Text IL-23 drives differentiation of peripheral 17 T cells from adult bone marrow-derived precursors JO: EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28855306 #FOAvip Pro-inflammatory interleukin (IL)-17-producing ?? (??17) T cells are thought to develop exclusively in the thymus during fetal/perinatal life, as adult bone marrow precursors fail to generate ??17 T cells under homeostatic conditions. Here, we employ a model of experimental autoimmune encephalomyelitis (EAE) in which hematopoiesis is reset by bone marrow transplantation and demonstrate unequivocally that V?4(+) ??17 T cells can develop de novo in draining lymph nodes in response to innate stimuli. In vitro, ?? T cells from IL-17 fate-mapping reporter mice that had never activated the Il17 locus acquire IL-17 expression upon stimulation with IL-1? and IL-23. Furthermore, IL-23R (but not IL-1R1) deficiency severely compromises the induction of ??17 T cells in EAE, demonstrating the key role of IL-23 in the process. Finally, we show, in a composite model involving transfers of both adult bone marrow and neonatal thymocytes, that induced ??17 T cells make up a substantial fraction of the total IL-17-producing V?4(+) T-cell pool upon inflammation, which attests the relevance of this novel pathway of peripheral ??17 T-cell differentiation. Twit Text FOAVip IL-23 drives differentiation of peripheral 17 T cells from adult bone marrow-derived precursors ????EMBO Rep http://www.kidney.de/pget.php?&tw=1&pmid=28855306 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28855306 #FOAvip English Wikipedia <ref>{{Cite pmid|28855306 }}</ref> IL-23 drives differentiation of peripheral ??17 T cells from adult bone marrow-derived precursors #MMPMID28855306 Papotto PH ; Gonçalves-Sousa N ; Schmolka N ; Iseppon A ; Mensurado S ; Stockinger B ; Ribot JC ; Silva-Santos B EMBO Rep 2017[Nov]; 18 (11 ): 1957-1967 PMID28855306 show ga Pro-inflammatory interleukin (IL)-17-producing ?? (??17) T cells are thought to develop exclusively in the thymus during fetal/perinatal life, as adult bone marrow precursors fail to generate ??17 T cells under homeostatic conditions. Here, we employ a model of experimental autoimmune encephalomyelitis (EAE) in which hematopoiesis is reset by bone marrow transplantation and demonstrate unequivocally that V?4(+) ??17 T cells can develop de novo in draining lymph nodes in response to innate stimuli. In vitro, ?? T cells from IL-17 fate-mapping reporter mice that had never activated the Il17 locus acquire IL-17 expression upon stimulation with IL-1? and IL-23. Furthermore, IL-23R (but not IL-1R1) deficiency severely compromises the induction of ??17 T cells in EAE, demonstrating the key role of IL-23 in the process. Finally, we show, in a composite model involving transfers of both adult bone marrow and neonatal thymocytes, that induced ??17 T cells make up a substantial fraction of the total IL-17-producing V?4(+) T-cell pool upon inflammation, which attests the relevance of this novel pathway of peripheral ??17 T-cell differentiation. |Animals [MESH] |Bone Marrow Transplantation [MESH] |Bone Marrow/immunology/pathology [MESH] |Cell Differentiation/drug effects [MESH] |Cell Lineage/immunology [MESH] |Cell Movement [MESH] |Encephalomyelitis, Autoimmune, Experimental/genetics/*immunology/pathology [MESH] |Gene Expression Regulation [MESH] |Hematopoiesis/immunology [MESH] |Interleukin-17/genetics/immunology [MESH] |Interleukin-1beta/genetics/immunology/pharmacology [MESH] |Interleukin-23/genetics/*immunology/pharmacology [MESH] |Lymph Nodes/*immunology/pathology [MESH] |Lymphocyte Activation/drug effects [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Transgenic [MESH] |Receptors, Antigen, T-Cell, gamma-delta/genetics/*immunology [MESH] |Receptors, Interleukin/genetics/immunology [MESH] |Signal Transduction [MESH] |Th17 Cells/*immunology/pathology [MESH]IL-23 drives differentiation of peripheral ??17 T cells from adult bon(epmc).pdf DeepDyve Pubget Overpricing