Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.15252/embj.201796525 http://scihub22266oqcxt.onion/10.15252/embj.201796525 C5666606!5666606 !29030483     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29030483 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       EMBO+J 2017 ; 36 (21 ): 3232-3249 Nephropedia Template TP {{tp|p=29030483 |t=2017. RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1 |pdf=|usr=}}{{29030483 }} gab.com Text RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1 JO: EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=29030483 #FOAvip Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the nucleus and forms a complex with the transcription factor RBPJ (also known as CBF1 or CSL) to activate expression of Notch target genes. In the absence of a Notch signal, RBPJ acts as a transcriptional repressor. Using a proteomic approach, we identified L3MBTL3 (also known as MBT1) as a novel RBPJ interactor. L3MBTL3 competes with NOTCH ICD for binding to RBPJ In the absence of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression. Importantly, in vivo analyses of the homologs of RBPJ and L3MBTL3 in Drosophila melanogaster and Caenorhabditis elegans demonstrate that the functional link between RBPJ and L3MBTL3 is evolutionarily conserved, thus identifying L3MBTL3 as a universal modulator of Notch signaling in metazoans. Twit Text FOAVip RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1 ????EMBO J http://www.kidney.de/pget.php?&tw=1&pmid=29030483 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29030483 #FOAvip English Wikipedia <ref>{{Cite pmid|29030483 }}</ref> RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch signaling via histone demethylase KDM1A/LSD1 #MMPMID29030483 Xu T ; Park SS ; Giaimo BD ; Hall D ; Ferrante F ; Ho DM ; Hori K ; Anhezini L ; Ertl I ; Bartkuhn M ; Zhang H ; Milon E ; Ha K ; Conlon KP ; Kuick R ; Govindarajoo B ; Zhang Y ; Sun Y ; Dou Y ; Basrur V ; Elenitoba-Johnson KS ; Nesvizhskii AI ; Ceron J ; Lee CY ; Borggrefe T ; Kovall RA ; Rual JF EMBO J 2017[Nov]; 36 (21 ): 3232-3249 PMID29030483 show ga Notch signaling is an evolutionarily conserved signal transduction pathway that is essential for metazoan development. Upon ligand binding, the Notch intracellular domain (NOTCH ICD) translocates into the nucleus and forms a complex with the transcription factor RBPJ (also known as CBF1 or CSL) to activate expression of Notch target genes. In the absence of a Notch signal, RBPJ acts as a transcriptional repressor. Using a proteomic approach, we identified L3MBTL3 (also known as MBT1) as a novel RBPJ interactor. L3MBTL3 competes with NOTCH ICD for binding to RBPJ In the absence of NOTCH ICD, RBPJ recruits L3MBTL3 and the histone demethylase KDM1A (also known as LSD1) to the enhancers of Notch target genes, leading to H3K4me2 demethylation and to transcriptional repression. Importantly, in vivo analyses of the homologs of RBPJ and L3MBTL3 in Drosophila melanogaster and Caenorhabditis elegans demonstrate that the functional link between RBPJ and L3MBTL3 is evolutionarily conserved, thus identifying L3MBTL3 as a universal modulator of Notch signaling in metazoans. |Animals [MESH] |Biological Evolution [MESH] |Caenorhabditis elegans/genetics/metabolism [MESH] |Cell Line, Tumor [MESH] |Conserved Sequence [MESH] |DNA-Binding Proteins/*genetics/metabolism [MESH] |Drosophila Proteins/*genetics/metabolism [MESH] |Drosophila melanogaster/genetics/metabolism [MESH] |Gene Expression Regulation [MESH] |Histone Demethylases/*genetics/metabolism [MESH] |Histones/genetics/metabolism [MESH] |Humans [MESH] |Immunoglobulin J Recombination Signal Sequence-Binding Protein/*genetics/metabolism [MESH] |Neuroglia/cytology/*metabolism [MESH] |Protein Binding [MESH] |Protein Domains [MESH] |Receptors, Notch/*genetics/metabolism [MESH] |Transcription, Genetic [MESH]RBPJ/CBF1 interacts with L3MBTL3/MBT1 to promote repression of Notch s(epmc).pdf DeepDyve Pubget Overpricing