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10.7150/ijms.20303 http://scihub22266oqcxt.onion/10.7150/ijms.20303 C5666555!5666555 !29104478     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=29104478 &cmd=llinks): Failed to open stream: HTTP request failed! 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Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1?,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee |pdf=|usr=}}{{29104478 }} gab.com Text Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1 ,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee JO: Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=29104478 #FOAvip The goal of our research was demonstrated that multiple molecules in microenvironments of the early osteoarthritis (OA) joint tissue may be actively responded to extracorporeal shockwave therapy (ESWT) treatment, which potentially regulated biological function of chondrocytes and synovial cells in early OA knee. We demonstrated that shockwave treatment induced the expression of protein-disulfide isomerase-associated 3 (Pdia-3) which was a significant mediator of the 1?,25-Dihydroxyvitamin D 3 (1?,25(OH)2D3) rapid signaling pathway, using two-dimensional electrophoresis, histological analysis and quantitative polymerase chain reaction (qPCR). We observed that the expression of Pdia-3 at 2 weeks was significantly higher than that of other group at 4, 8, and 12 weeks post-shockwave treatment in early OA rat knee model. The other factors of the rapid membrane signaling pathway, including extracellular signal-regulated protein kinases 1 (ERK1), osteopontin (OPG), alkaline phosphatase (ALP), and matrix metallopeptidase 13 (MMP13) were examined and were found to be significantly increased at 2 weeks post-shockwave treatment by qPCR in early OA of the knee. Our proteomic data revealed significant Pdia-3 expression in microenvironments of OA joint tissue that could be actively responded to ESWT, which may potentially regulate the biological functions of chondrocytes and osteoblasts in the treatment of the early OA of the knee. Twit Text FOAVip Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1 ,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee ????Int J Med Sci http://www.kidney.de/pget.php?&tw=1&pmid=29104478 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29104478 #FOAvip English Wikipedia <ref>{{Cite pmid|29104478 }}</ref> Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which Is a Key Factor of the 1?,25-Dihydroxyvitamin D 3 Rapid Membrane Signaling Pathway in Treatment of Early Osteoarthritis of the Knee #MMPMID29104478 Hsu SL ; Cheng JH ; Wang CJ ; Ko JY ; Hsu CH Int J Med Sci 2017[]; 14 (12 ): 1220-1230 PMID29104478 show ga The goal of our research was demonstrated that multiple molecules in microenvironments of the early osteoarthritis (OA) joint tissue may be actively responded to extracorporeal shockwave therapy (ESWT) treatment, which potentially regulated biological function of chondrocytes and synovial cells in early OA knee. We demonstrated that shockwave treatment induced the expression of protein-disulfide isomerase-associated 3 (Pdia-3) which was a significant mediator of the 1?,25-Dihydroxyvitamin D 3 (1?,25(OH)2D3) rapid signaling pathway, using two-dimensional electrophoresis, histological analysis and quantitative polymerase chain reaction (qPCR). We observed that the expression of Pdia-3 at 2 weeks was significantly higher than that of other group at 4, 8, and 12 weeks post-shockwave treatment in early OA rat knee model. The other factors of the rapid membrane signaling pathway, including extracellular signal-regulated protein kinases 1 (ERK1), osteopontin (OPG), alkaline phosphatase (ALP), and matrix metallopeptidase 13 (MMP13) were examined and were found to be significantly increased at 2 weeks post-shockwave treatment by qPCR in early OA of the knee. Our proteomic data revealed significant Pdia-3 expression in microenvironments of OA joint tissue that could be actively responded to ESWT, which may potentially regulate the biological functions of chondrocytes and osteoblasts in the treatment of the early OA of the knee. |*Extracorporeal Shockwave Therapy [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Cell Membrane/metabolism/radiation effects [MESH] |Cellular Microenvironment/radiation effects [MESH] |Chondrocytes/metabolism/radiation effects [MESH] |Disease Models, Animal [MESH] |Humans [MESH] |Knee Joint/cytology/metabolism/radiation effects [MESH] |Male [MESH] |Osteoarthritis, Knee/*therapy [MESH] |Osteoblasts/metabolism/radiation effects [MESH] |Protein Disulfide-Isomerases/*metabolism [MESH] |Proteomics [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH]Extracorporeal Shockwave Therapy Enhances Expression of Pdia-3 Which I(epmc).pdf DeepDyve Pubget Overpricing