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10.15252/emmm.201707732 http://scihub22266oqcxt.onion/10.15252/emmm.201707732 C5666309!5666309!28899929     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       EMBO+Mol+Med 2017 ; 9 (11): 1482-90 Nephropedia Template TP {{tp|p=28899929|t=2017. Pathogen?specific B?cell receptors drive chronic lymphocytic leukemia by light?chain?dependent cross?reaction with autoantigens |pdf=|usr=}}{{28899929}} gab.com Text Pathogen specific B cell receptors drive chronic lymphocytic leukemia by light chain dependent cross reaction with autoantigens JO: EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28899929 #FOAvip Several lines of evidence indirectly suggest that antigenic stimulation through the B?cell receptor (BCR) supports chronic lymphocytic leukemia (CLL) development. In addition to self?antigens, a number of microbial antigens have been proposed to contribute to the selection of the immunoglobulins expressed in CLL. How pathogen?specific BCRs drive CLL development remains, however, largely unexplored. Here, we utilized mouse models of CLL pathogenesis to equip B cells with virus?specific BCRs and study the effect of antigen recognition on leukemia growth. Our results show that BCR engagement is absolutely required for CLL development. Unexpectedly, however, neither acute nor chronic exposure to virus?derived antigens influenced leukemia progression. Rather, CLL clones preferentially selected light chains that, when paired with virus?specific heavy chains, conferred B cells the ability to recognize a broad range of autoantigens. Taken together, our results suggest that pathogens may drive CLL pathogenesis by selecting and expanding pathogen?specific B cells that cross?react with one or more self?antigens. Twit Text FOAVip Pathogen specific B cell receptors drive chronic lymphocytic leukemia by light chain dependent cross reaction with autoantigens ????EMBO Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28899929 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28899929 #FOAvip English Wikipedia <ref>{{Cite pmid|28899929}}</ref> Pathogen?specific B?cell receptors drive chronic lymphocytic leukemia by light?chain?dependent cross?reaction with autoantigens #MMPMID28899929 Jiménez de Oya N; De Giovanni M; Fioravanti J; Übelhart R; Di Lucia P; Fiocchi A; Iacovelli S; Efremov DG; Caligaris?Cappio F; Jumaa H; Ghia P; Guidotti LG; Iannacone M EMBO Mol Med 2017[Nov]; 9 (11): 1482-90 PMID28899929show ga Several lines of evidence indirectly suggest that antigenic stimulation through the B?cell receptor (BCR) supports chronic lymphocytic leukemia (CLL) development. In addition to self?antigens, a number of microbial antigens have been proposed to contribute to the selection of the immunoglobulins expressed in CLL. How pathogen?specific BCRs drive CLL development remains, however, largely unexplored. Here, we utilized mouse models of CLL pathogenesis to equip B cells with virus?specific BCRs and study the effect of antigen recognition on leukemia growth. Our results show that BCR engagement is absolutely required for CLL development. Unexpectedly, however, neither acute nor chronic exposure to virus?derived antigens influenced leukemia progression. Rather, CLL clones preferentially selected light chains that, when paired with virus?specific heavy chains, conferred B cells the ability to recognize a broad range of autoantigens. Taken together, our results suggest that pathogens may drive CLL pathogenesis by selecting and expanding pathogen?specific B cells that cross?react with one or more self?antigens. äPathogen?specific B?cell receptors drive chronic lymphocytic leukemia (epmc).pdf DeepDyve Pubget Overpricing