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10.1016/j.str.2017.04.005 http://scihub22266oqcxt.onion/10.1016/j.str.2017.04.005 C5666114!5666114 !28479063     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 249.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28479063 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Structure 2017 ; 25 (6 ): 834-845.e5 Nephropedia Template TP {{tp|p=28479063 |t=2017. The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System |pdf=|usr=}}{{28479063 }} gab.com Text The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System JO: Structure http://www.kidney.de/pget.php?&tw=1&pmid=28479063 #FOAvip Proteasomes are self-compartmentalizing proteases that function at the core of the cellular protein degradation machinery in eukaryotes, archaea, and some bacteria. Although their evolutionary history is under debate, it is thought to be linked to that of the bacterial protease HslV and the hypothetical bacterial protease Anbu (ancestral beta subunit). Here, together with an extensive bioinformatic analysis, we present the first biophysical characterization of Anbu. Anbu forms a dodecameric complex with a unique architecture that was only accessible through the combination of X-ray crystallography and small-angle X-ray scattering. While forming continuous helices in crystals and electron microscopy preparations, refinement of sections from the crystal structure against the scattering data revealed a helical open-ring structure in solution, contrasting the ring-shaped structures of proteasome and HslV. Based on this primordial architecture and exhaustive sequence comparisons, we propose that Anbu represents an ancestral precursor at the origin of self-compartmentalization. Twit Text FOAVip The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System ????Structure http://www.kidney.de/pget.php?&tw=1&pmid=28479063 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28479063 #FOAvip English Wikipedia <ref>{{Cite pmid|28479063 }}</ref> The Architecture of the Anbu Complex Reflects an Evolutionary Intermediate at the Origin of the Proteasome System #MMPMID28479063 Fuchs ACD ; Alva V ; Maldoner L ; Albrecht R ; Hartmann MD ; Martin J Structure 2017[Jun]; 25 (6 ): 834-845.e5 PMID28479063 show ga Proteasomes are self-compartmentalizing proteases that function at the core of the cellular protein degradation machinery in eukaryotes, archaea, and some bacteria. Although their evolutionary history is under debate, it is thought to be linked to that of the bacterial protease HslV and the hypothetical bacterial protease Anbu (ancestral beta subunit). Here, together with an extensive bioinformatic analysis, we present the first biophysical characterization of Anbu. Anbu forms a dodecameric complex with a unique architecture that was only accessible through the combination of X-ray crystallography and small-angle X-ray scattering. While forming continuous helices in crystals and electron microscopy preparations, refinement of sections from the crystal structure against the scattering data revealed a helical open-ring structure in solution, contrasting the ring-shaped structures of proteasome and HslV. Based on this primordial architecture and exhaustive sequence comparisons, we propose that Anbu represents an ancestral precursor at the origin of self-compartmentalization. |*Evolution, Molecular [MESH] |Bacterial Proteins/*chemistry/metabolism [MESH] |Catalytic Domain [MESH] |Cloning, Molecular [MESH] |Crystallography, X-Ray [MESH] |Models, Molecular [MESH] |Proteasome Endopeptidase Complex/chemistry/*metabolism [MESH] |Protein Conformation [MESH] |Protein Multimerization [MESH] |Scattering, Small Angle [MESH]The Architecture of the Anbu Complex Reflects an Evolutionary Intermed(epmc).pdf DeepDyve Pubget Overpricing