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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Am+J+Transl+Res
2017 ; 9
(10
): 4617-4626
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gab.com Text
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English Wikipedia
IL-6 increases SDCBP expression, cell proliferation, and cell invasion by
activating JAK2/STAT3 in human glioma cells
#MMPMID29118922
Cao F
; Zhang Q
; Chen W
; Han C
; He Y
; Ran Q
; Yao S
Am J Transl Res
2017[]; 9
(10
): 4617-4626
PMID29118922
show ga
Syndecan-binding protein (SDCBP), which is induced by tumor necrosis factor-? and
interferon-?, controls the proliferation and invasion of several different types
of cancer cells. Interleukin-6 (IL-6) is known to play an important role in the
glioma cell growth and invasion. The present study aimed to investigate the
relationship between IL-6 and SDCBP in glioma cells. SDCBP expression was knocked
down in two glioma cell lines (T98G and U87) by small interfering RNA (siRNA)
transfection. Cell proliferation and invasion were significantly repressed
following SDCBP knockdown, and there was a positive correlation between SDCBP and
IL-6 expression levels in glioma tissues. IL-6 stimulation dose- and
time-dependently induced SDCBP expression at both mRNA and protein levels.
Furthermore, pre-treatment with the Janus kinase 2 (JAK2) inhibitor AG490
abolished the IL-6-induced SDCBP expression, suggesting that the effect of IL-6
on SDCBP transcription is dependent on JAK2/signal transducer and activator of
transcription 3 (STAT3) signaling. Finally, IL-6 did not stimulate glioma cell
growth or invasion when SDCBP expression was suppressed. In summary, our results
suggest that IL-6 promotes glioma cell proliferation and invasion by inducing
SDCBP expression, which is mediated by JAK2/STAT3 signaling.