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10.1111/cas.13354 http://scihub22266oqcxt.onion/10.1111/cas.13354 C5666038!5666038 !28803443     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28803443 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2017 ; 108 (11 ): 2248-2264 Nephropedia Template TP {{tp|p=28803443 |t=2017. Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3?/?-catenin pathway |pdf=|usr=}}{{28803443 }} gab.com Text Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3 / -catenin pathway JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28803443 #FOAvip Solasodine is a main active component isolated from Solanum incanum L. that performs a wide range of functions containing anti-oxidant, anti-infection, and neurogenesis promotion. In this study, we explored the influence of solasodine on three types of human colorectal cancer (CRC) cell lines. The results show that solasodine prohibited CRC cell proliferation dose- and time-dependently and impeded CRC cell motility by downregulating MMPs. Solasodine was also found to fuel caspase-cascade reaction and increase the ratio between Bax and Bcl-2 so as to induce CRC cell apoptosis. When cells were pretreated with AKT activator (insulin-like growth factor-1) followed by solasodine, the solasodine-induced apoptosis was partially abrogated by insulin-like growth factor-1. Moreover, solasodine hindered tumor development and stimulated similar mechanisms in vivo. In general, our study provides the first evidence that solasodine has a suppressive effect on CRC cells and that this agent may be a novel therapeutic drug for CRC treatment. Twit Text FOAVip Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3 / -catenin pathway ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28803443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28803443 #FOAvip English Wikipedia <ref>{{Cite pmid|28803443 }}</ref> Solasodine inhibits human colorectal cancer cells through suppression of the AKT/glycogen synthase kinase-3?/?-catenin pathway #MMPMID28803443 Zhuang YW ; Wu CE ; Zhou JY ; Chen X ; Wu J ; Jiang S ; Peng HY ; Zou X ; Liu JY ; Wu DP ; Gong T ; Qi MH ; Xue T ; Liu SL ; Cai H Cancer Sci 2017[Nov]; 108 (11 ): 2248-2264 PMID28803443 show ga Solasodine is a main active component isolated from Solanum incanum L. that performs a wide range of functions containing anti-oxidant, anti-infection, and neurogenesis promotion. In this study, we explored the influence of solasodine on three types of human colorectal cancer (CRC) cell lines. The results show that solasodine prohibited CRC cell proliferation dose- and time-dependently and impeded CRC cell motility by downregulating MMPs. Solasodine was also found to fuel caspase-cascade reaction and increase the ratio between Bax and Bcl-2 so as to induce CRC cell apoptosis. When cells were pretreated with AKT activator (insulin-like growth factor-1) followed by solasodine, the solasodine-induced apoptosis was partially abrogated by insulin-like growth factor-1. Moreover, solasodine hindered tumor development and stimulated similar mechanisms in vivo. In general, our study provides the first evidence that solasodine has a suppressive effect on CRC cells and that this agent may be a novel therapeutic drug for CRC treatment. |Apoptosis/drug effects [MESH] |Cell Line, Tumor [MESH] |Cell Movement/drug effects [MESH] |Cell Proliferation/*drug effects [MESH] |Colorectal Neoplasms/*drug therapy/genetics/pathology [MESH] |Dose-Response Relationship, Drug [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Glycogen Synthase Kinase 3 beta/genetics [MESH] |Humans [MESH] |Insulin-Like Growth Factor I/*administration & dosage [MESH] |Phosphorylation [MESH] |Proto-Oncogene Proteins c-akt/genetics [MESH] |Proto-Oncogene Proteins c-bcl-2/genetics [MESH] |Signal Transduction/drug effects [MESH] |Solanaceous Alkaloids/*administration & dosage [MESH]Solasodine inhibits human colorectal cancer cells through suppression (epmc).pdf DeepDyve Pubget Overpricing