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10.1111/cas.13380 http://scihub22266oqcxt.onion/10.1111/cas.13380 C5666033!5666033 !28837253     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28837253 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Sci 2017 ; 108 (11 ): 2187-2194 Nephropedia Template TP {{tp|p=28837253 |t=2017. Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 |pdf=|usr=}}{{28837253 }} gab.com Text Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28837253 #FOAvip In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron-dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to ferroptosis in oncogenic Ras-expressing cancer cells. Several 12/15-LOX inhibitors prevented cell death induced by erastin and RSL3. Furthermore, siRNA-mediated silencing of ALOX15 significantly decreased both erastin-induced and RSL3-induced ferroptotic cell death, whereas exogenous overexpression of ALOX15 enhanced the effect of these compounds. Immunofluorescence analyses revealed that the ALOX15 protein consistently localizes to cell membrane during the course of ferroptosis. Importantly, treatments of cells with ALOX15-activating compounds accelerated cell death at low, but not high doses of erastin and RSL3. These observations suggest that tumor ferroptosis is promoted by LOX-catalyzed lipid hydroperoxide generation in cellular membranes. Twit Text FOAVip Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28837253 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28837253 #FOAvip English Wikipedia <ref>{{Cite pmid|28837253 }}</ref> Lipoxygenase-mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3 #MMPMID28837253 Shintoku R ; Takigawa Y ; Yamada K ; Kubota C ; Yoshimoto Y ; Takeuchi T ; Koshiishi I ; Torii S Cancer Sci 2017[Nov]; 108 (11 ): 2187-2194 PMID28837253 show ga In cancer cells the small compounds erastin and RSL3 promote a novel type of cell death called ferroptosis, which requires iron-dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases (LOX) to ferroptosis in oncogenic Ras-expressing cancer cells. Several 12/15-LOX inhibitors prevented cell death induced by erastin and RSL3. Furthermore, siRNA-mediated silencing of ALOX15 significantly decreased both erastin-induced and RSL3-induced ferroptotic cell death, whereas exogenous overexpression of ALOX15 enhanced the effect of these compounds. Immunofluorescence analyses revealed that the ALOX15 protein consistently localizes to cell membrane during the course of ferroptosis. Importantly, treatments of cells with ALOX15-activating compounds accelerated cell death at low, but not high doses of erastin and RSL3. These observations suggest that tumor ferroptosis is promoted by LOX-catalyzed lipid hydroperoxide generation in cellular membranes. |Arachidonate 15-Lipoxygenase/*genetics [MESH] |Carbolines/administration & dosage [MESH] |Cell Death/*drug effects [MESH] |Cell Line, Tumor [MESH] |Fibrosarcoma/drug therapy/*genetics/pathology [MESH] |Gene Expression Regulation, Neoplastic/drug effects [MESH] |Humans [MESH] |Lipid Peroxidation/drug effects [MESH] |Pancreatic Neoplasms/drug therapy/*genetics/pathology [MESH] |Piperazines/administration & dosage [MESH]Lipoxygenase-mediated generation of lipid peroxides enhances ferroptos(epmc).pdf DeepDyve Pubget Overpricing