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10.1111/cas.13387 http://scihub22266oqcxt.onion/10.1111/cas.13387 C5666029!5666029 !28846190     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28846190 &cmd=llinks): Failed to open stream: HTTP request failed! 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Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes |pdf=|usr=}}{{28846190 }} gab.com Text Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes JO: Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28846190 #FOAvip Systemic administration of drugs into the blood circulation is standard treatment for prevention of metastasis. However, systemic delivery cannot maintain sufficiently high concentrations of anticancer drugs in lymph nodes (LN). Here, we show that giving cisplatin (CDDP) using a lymphatic drug delivery system (LDDS) has the potential to treat false-negative metastatic LN. We found that in MXH10/Mo-lpr/lpr mice, which develop systemic swelling of LN up to 10 mm in diameter, accumulation of indocyanine green (ICG), which has a similar molecular weight to CDDP, in a target LN was greater for lymphatic delivery of ICG than for systemic (i.v.) administration. Furthermore, CDDP administration with a LDDS inhibited tumor growth in false-negative metastatic LN and produced fewer adverse effects than systemically given CDDP. We anticipate that drug delivery using a LDDS will, in time, replace systemic chemotherapy for the treatment of false-negative metastatic LN. Twit Text FOAVip Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes ????Cancer Sci http://www.kidney.de/pget.php?&tw=1&pmid=28846190 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28846190 #FOAvip English Wikipedia <ref>{{Cite pmid|28846190 }}</ref> Therapeutic effect of cisplatin given with a lymphatic drug delivery system on false-negative metastatic lymph nodes #MMPMID28846190 Tada A ; Horie S ; Mori S ; Kodama T Cancer Sci 2017[Nov]; 108 (11 ): 2115-2121 PMID28846190 show ga Systemic administration of drugs into the blood circulation is standard treatment for prevention of metastasis. However, systemic delivery cannot maintain sufficiently high concentrations of anticancer drugs in lymph nodes (LN). Here, we show that giving cisplatin (CDDP) using a lymphatic drug delivery system (LDDS) has the potential to treat false-negative metastatic LN. We found that in MXH10/Mo-lpr/lpr mice, which develop systemic swelling of LN up to 10 mm in diameter, accumulation of indocyanine green (ICG), which has a similar molecular weight to CDDP, in a target LN was greater for lymphatic delivery of ICG than for systemic (i.v.) administration. Furthermore, CDDP administration with a LDDS inhibited tumor growth in false-negative metastatic LN and produced fewer adverse effects than systemically given CDDP. We anticipate that drug delivery using a LDDS will, in time, replace systemic chemotherapy for the treatment of false-negative metastatic LN. |*Drug Delivery Systems [MESH] |Animals [MESH] |Cisplatin/*administration & dosage/adverse effects [MESH] |Female [MESH] |Humans [MESH] |Indocyanine Green/chemistry [MESH] |Lymph Nodes/drug effects/pathology [MESH] |Lymphatic Metastasis [MESH] |Lymphatic Vessels/drug effects/pathology [MESH] |Mammary Neoplasms, Animal/*drug therapy/genetics/pathology [MESH]Therapeutic effect of cisplatin given with a lymphatic drug delivery s(epmc).pdf DeepDyve Pubget Overpricing