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10.1038/s41467-017-01170-7 http://scihub22266oqcxt.onion/10.1038/s41467-017-01170-7 C5665913!5665913 !29093447     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 263.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29093447 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2017 ; 8 (1 ): 1250 Nephropedia Template TP {{tp|p=29093447 |t=2017. E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning |pdf=|usr=}}{{29093447 }} gab.com Text E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29093447 #FOAvip Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount imaging, genetic ablation, and traction force microscopy and atomic force microscopy, we find that ubiquitously localized E-cadherin coordinates tissue polarization of tension-bearing adherens junction (AJ) and F-actin organization to allow formation of an apical TJ network only in the uppermost viable layer. Molecularly, E-cadherin localizes and tunes EGFR activity and junctional tension to inhibit premature TJ complex formation in lower layers while promoting increased tension and TJ stability in the granular layer 2. In conclusion, our data identify an E-cadherin-dependent mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive the polarized organization of junctional tension necessary to build an in vivo epithelial barrier. Twit Text FOAVip E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29093447 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29093447 #FOAvip English Wikipedia <ref>{{Cite pmid|29093447 }}</ref> E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning #MMPMID29093447 Rübsam M ; Mertz AF ; Kubo A ; Marg S ; Jüngst C ; Goranci-Buzhala G ; Schauss AC ; Horsley V ; Dufresne ER ; Moser M ; Ziegler W ; Amagai M ; Wickström SA ; Niessen CM Nat Commun 2017[Nov]; 8 (1 ): 1250 PMID29093447 show ga Generation of a barrier in multi-layered epithelia like the epidermis requires restricted positioning of functional tight junctions (TJ) to the most suprabasal viable layer. This positioning necessitates tissue-level polarization of junctions and the cytoskeleton through unknown mechanisms. Using quantitative whole-mount imaging, genetic ablation, and traction force microscopy and atomic force microscopy, we find that ubiquitously localized E-cadherin coordinates tissue polarization of tension-bearing adherens junction (AJ) and F-actin organization to allow formation of an apical TJ network only in the uppermost viable layer. Molecularly, E-cadherin localizes and tunes EGFR activity and junctional tension to inhibit premature TJ complex formation in lower layers while promoting increased tension and TJ stability in the granular layer 2. In conclusion, our data identify an E-cadherin-dependent mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive the polarized organization of junctional tension necessary to build an in vivo epithelial barrier. |*Mechanotransduction, Cellular [MESH] |Actin Cytoskeleton/metabolism [MESH] |Actins/metabolism [MESH] |Adherens Junctions/*metabolism/ultrastructure [MESH] |Animals [MESH] |Cadherins/*metabolism [MESH] |Cell Differentiation [MESH] |Cell Proliferation [MESH] |Epidermis/*metabolism/ultrastructure [MESH] |ErbB Receptors/*metabolism [MESH] |Mice [MESH] |Mice, Knockout [MESH] |Microscopy, Atomic Force [MESH] |Signal Transduction [MESH]E-cadherin integrates mechanotransduction and EGFR signaling to contro(epmc).pdf DeepDyve Pubget Overpricing