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10.1038/s41467-017-01255-3 http://scihub22266oqcxt.onion/10.1038/s41467-017-01255-3 C5665887!5665887!29093443     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2017 ; 8 (ä): ä Nephropedia Template TP {{tp|p=29093443|t=2017. Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells |pdf=|usr=}}{{29093443}} gab.com Text Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29093443 #FOAvip Yes-associated protein (YAP) is a recently discovered growth-promoting transcription coactivator that has been shown to regulate the malignancy of various cancers. How YAP is regulated is not fully understood. Here, we show that one of the factors regulating YAP is phosphatidylserine (PS) in recycling endosomes (REs). We use proximity biotinylation to find proteins proximal to PS. Among these proteins are YAP and multiple proteins related to YAP signalling. Knockdown of ATP8A1 (an RE PS-flippase) or evectin-2 (an RE-resident protein) and masking of PS in the cytoplasmic leaflet of membranes, all suppress nuclear localization of YAP and YAP-dependent transcription. ATP8A1 knockdown increases the phosphorylated (activated) form of Lats1 that phosphorylates and inactivates YAP, whereas evectin-2 knockdown reduces the ubiquitination and increased the level of Lats1. The proliferation of YAP-dependent metastatic cancer cells is suppressed by knockdown of ATP8A1 or evectin-2. These results suggest a link between a membrane phospholipid and cell proliferation. Twit Text FOAVip Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=29093443 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29093443 #FOAvip English Wikipedia <ref>{{Cite pmid|29093443}}</ref> Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells #MMPMID29093443 Matsudaira T; Mukai K; Noguchi T; Hasegawa J; Hatta T; Iemura Si; Natsume T; Miyamura N; Nishina H; Nakayama J; Semba K; Tomita T; Murata S; Arai H; Taguchi T Nat Commun 2017[]; 8 (ä): ä PMID29093443show ga Yes-associated protein (YAP) is a recently discovered growth-promoting transcription coactivator that has been shown to regulate the malignancy of various cancers. How YAP is regulated is not fully understood. Here, we show that one of the factors regulating YAP is phosphatidylserine (PS) in recycling endosomes (REs). We use proximity biotinylation to find proteins proximal to PS. Among these proteins are YAP and multiple proteins related to YAP signalling. Knockdown of ATP8A1 (an RE PS-flippase) or evectin-2 (an RE-resident protein) and masking of PS in the cytoplasmic leaflet of membranes, all suppress nuclear localization of YAP and YAP-dependent transcription. ATP8A1 knockdown increases the phosphorylated (activated) form of Lats1 that phosphorylates and inactivates YAP, whereas evectin-2 knockdown reduces the ubiquitination and increased the level of Lats1. The proliferation of YAP-dependent metastatic cancer cells is suppressed by knockdown of ATP8A1 or evectin-2. These results suggest a link between a membrane phospholipid and cell proliferation. äEndosomal phosphatidylserine is critical for the YAP signalling pathwa(epmc).pdf DeepDyve Pubget Overpricing