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Deprecated: Implicit conversion from float 298.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Cancer+Sci 2017 ; 108 (11): 2130-41 Nephropedia Template TP
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Dermokine contributes to epithelial?mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer #MMPMID28795470
Huang C; Xiang Y; Chen S; Yu H; Wen Z; Ye T; Sun H; Kong H; Li D; Yu D; Chen B; Zhou M
Cancer Sci 2017[Nov]; 108 (11): 2130-41 PMID28795470show ga
Dermokine (DMKN) was first identified in relation to skin lesion healing and skin carcinoma. Recently, its expression was associated with pancreatic cancer tumorigenesis, although its involvement remains poorly understood. Herein, we showed that DMKN loss of function in Patu?8988 and PANC?1 pancreatic cancer cell lines resulted in reduced phosphorylation of signal transducer and activator of transcription 3, and increased activation of ERK1/2 and AKT serine/threonine kinase. This decreased the proliferation ability of pancreatic ductal adenocarcinoma (PDAC) cells. In addition, DMKN knockdown decreased the invasion and migration of PDAC cells, partially reversed the epithelial?mesenchymal transition, retarded tumor growth in a xenograft animal model by decreasing the density of microvessels, and attenuated the distant metastasis of human PDAC in a mouse model. Taken together, these data suggested that DMKN could be a potential prognostic biomarker and therapeutic target in pancreatic cancer.