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10.1242/dev.154971 http://scihub22266oqcxt.onion/10.1242/dev.154971 C5665486!5665486 !28893948     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28893948 &cmd=llinks): Failed to open stream: HTTP request failed! 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Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians |pdf=|usr=}}{{28893948 }} gab.com Text Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians JO: Development http://www.kidney.de/pget.php?&tw=1&pmid=28893948 #FOAvip Migration of stem cells underpins the physiology of metazoan animals. For tissues to be maintained, stem cells and their progeny must migrate and differentiate in the correct positions. This need is even more acute after tissue damage by wounding or pathogenic infection. Inappropriate migration also underpins metastasis. Despite this, few mechanistic studies address stem cell migration during repair or homeostasis in adult tissues. Here, we present a shielded X-ray irradiation assay that allows us to follow stem cell migration in planarians. We demonstrate the use of this system to study the molecular control of stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homologs are necessary for cell migration to wound sites and for the establishment of migratory cell morphology. We also observed that stem cells undergo homeostatic migration to anterior regions that lack local stem cells, in the absence of injury, maintaining tissue homeostasis. This requires the polarity determinant notum Our work establishes planarians as a suitable model for further in-depth study of the processes controlling stem cell migration in vivo. Twit Text FOAVip Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians ????Development http://www.kidney.de/pget.php?&tw=1&pmid=28893948 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28893948 #FOAvip English Wikipedia <ref>{{Cite pmid|28893948 }}</ref> Epithelial-mesenchymal transition transcription factors control pluripotent adult stem cell migration in vivo in planarians #MMPMID28893948 Abnave P ; Aboukhatwa E ; Kosaka N ; Thompson J ; Hill MA ; Aboobaker AA Development 2017[Oct]; 144 (19 ): 3440-3453 PMID28893948 show ga Migration of stem cells underpins the physiology of metazoan animals. For tissues to be maintained, stem cells and their progeny must migrate and differentiate in the correct positions. This need is even more acute after tissue damage by wounding or pathogenic infection. Inappropriate migration also underpins metastasis. Despite this, few mechanistic studies address stem cell migration during repair or homeostasis in adult tissues. Here, we present a shielded X-ray irradiation assay that allows us to follow stem cell migration in planarians. We demonstrate the use of this system to study the molecular control of stem cell migration and show that snail-1, snail-2 and zeb-1 EMT transcription factor homologs are necessary for cell migration to wound sites and for the establishment of migratory cell morphology. We also observed that stem cells undergo homeostatic migration to anterior regions that lack local stem cells, in the absence of injury, maintaining tissue homeostasis. This requires the polarity determinant notum Our work establishes planarians as a suitable model for further in-depth study of the processes controlling stem cell migration in vivo. |*Cell Movement/radiation effects [MESH] |*Epithelial-Mesenchymal Transition/radiation effects [MESH] |Adult Stem Cells/*cytology/metabolism/radiation effects [MESH] |Animals [MESH] |Cell Lineage/radiation effects [MESH] |Cell Shape/radiation effects [MESH] |Conserved Sequence [MESH] |Epidermal Cells [MESH] |Integrin beta Chains/metabolism [MESH] |Matrix Metalloproteinases/metabolism [MESH] |Planarians/*cytology/genetics/*metabolism [MESH] |Pluripotent Stem Cells/*cytology/radiation effects [MESH] |Snail Family Transcription Factors/metabolism [MESH] |Transcription Factors/*metabolism [MESH]Epithelial-mesenchymal transition transcription factors control plurip(epmc).pdf DeepDyve Pubget Overpricing