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10.1242/bio.026039 http://scihub22266oqcxt.onion/10.1242/bio.026039 C5665464!5665464!28821490     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biol+Open 2017 ; 6 (10): 1458-71 Nephropedia Template TP {{tp|p=28821490|t=2017. SERCA directs cell migration and branching across species and germ layers |pdf=|usr=}}{{28821490}} gab.com Text SERCA directs cell migration and branching across species and germ layers JO: Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=28821490 #FOAvip Branching morphogenesis underlies organogenesis in vertebrates and invertebrates, yet is incompletely understood. Here, we show that the sarco-endoplasmic reticulum Ca2+ reuptake pump (SERCA) directs budding across germ layers and species. Clonal knockdown demonstrated a cell-autonomous role for SERCA in Drosophila air sac budding. Live imaging of Drosophila tracheogenesis revealed elevated Ca2+ levels in migratory tip cells as they form branches. SERCA blockade abolished this Ca2+ differential, aborting both cell migration and new branching. Activating protein kinase C (PKC) rescued Ca2+ in tip cells and restored cell migration and branching. Likewise, inhibiting SERCA abolished mammalian epithelial budding, PKC activation rescued budding, while morphogens did not. Mesoderm (zebrafish angiogenesis) and ectoderm (Drosophila nervous system) behaved similarly, suggesting a conserved requirement for cell-autonomous Ca2+ signaling, established by SERCA, in iterative budding. Twit Text FOAVip SERCA directs cell migration and branching across species and germ layers ????Biol Open http://www.kidney.de/pget.php?&tw=1&pmid=28821490 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28821490 #FOAvip English Wikipedia <ref>{{Cite pmid|28821490}}</ref> SERCA directs cell migration and branching across species and germ layers #MMPMID28821490 Bower DV; Lansdale N; Navarro S; Truong TV; Bower DJ; Featherstone NC; Connell MG; Al Alam D; Frey MR; Trinh LA; Fernandez GE; Warburton D; Fraser SE; Bennett D; Jesudason EC Biol Open 2017[Oct]; 6 (10): 1458-71 PMID28821490show ga Branching morphogenesis underlies organogenesis in vertebrates and invertebrates, yet is incompletely understood. Here, we show that the sarco-endoplasmic reticulum Ca2+ reuptake pump (SERCA) directs budding across germ layers and species. Clonal knockdown demonstrated a cell-autonomous role for SERCA in Drosophila air sac budding. Live imaging of Drosophila tracheogenesis revealed elevated Ca2+ levels in migratory tip cells as they form branches. SERCA blockade abolished this Ca2+ differential, aborting both cell migration and new branching. Activating protein kinase C (PKC) rescued Ca2+ in tip cells and restored cell migration and branching. Likewise, inhibiting SERCA abolished mammalian epithelial budding, PKC activation rescued budding, while morphogens did not. Mesoderm (zebrafish angiogenesis) and ectoderm (Drosophila nervous system) behaved similarly, suggesting a conserved requirement for cell-autonomous Ca2+ signaling, established by SERCA, in iterative budding. äSERCA directs cell migration and branching across species and germ lay(epmc).pdf DeepDyve Pubget Overpricing